PDF(Pubmed)
Abstract：
UNASSIGNED: The anterior (AcomA) and posterior communicating arteries (PcomA) are two of the most frequent sites for intracranial aneurysms. Anatomical variations in the Circle of Willis (COW) are frequently observed in patients with AcomA and PcomA aneurysms. Strong evidence is needed to determine the pooled estimate of the effect of COW variations on the formation and rupture of these aneurysms.
UNASSIGNED: This systematic review and meta-analysis aimed to establish the effect of COW variations on the formation and rupture of AcomA and PcomA aneurysms using available studies.
UNASSIGNED: PubMed, Embase, and Web of Science databases were systematically searched for studies published in English before September 21, 2022. Studies investigating AcomA aneurysms and the hypoplastic/aplastic A1 segment of the anterior cerebral artery and PcomA aneurysms and hypoplastic/aplastic PcomA or fetal-type posterior cerebral artery (FTP) were included. The heterogeneity of the studies was assessed using Cochran Q-test and I2 statistic. Pooled estimate was assessed using either a random- or fixed-effects model based on the heterogeneity of the studies. Among the 4,932 studies, 21 were eligible and included in the analysis. The presence of hypoplastic/aplastic A1 was significantly correlated with the formation [OR (95% confidence interval [CI]) = 7.97 (5.58, 11.39), P < 0.001] and rupture [OR (95%CI) = 1.87 (1.29, 2.72), P < 0.001] of AcomA aneurysms. Significant associations between FTP and both the formation [OR (95%CI) = 2.15 (1.41, 3.30), P < 0.001] and rupture [OR (95%CI) = 1.72 (1.26, 2.36), P < 0.001] of PcomA aneurysms were observed.
UNASSIGNED: Significant associations were observed between COW variations and both the formation and rupture of AcomA and PcomA aneurysms. This can help in determining interventions for patients with aneurysms.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=225149, identifier: CRD42021225149.
UNASSIGNED: This systematic review and meta-analysis aimed to establish the effect of COW variations on the formation and rupture of AcomA and PcomA aneurysms using available studies.
UNASSIGNED: PubMed, Embase, and Web of Science databases were systematically searched for studies published in English before September 21, 2022. Studies investigating AcomA aneurysms and the hypoplastic/aplastic A1 segment of the anterior cerebral artery and PcomA aneurysms and hypoplastic/aplastic PcomA or fetal-type posterior cerebral artery (FTP) were included. The heterogeneity of the studies was assessed using Cochran Q-test and I2 statistic. Pooled estimate was assessed using either a random- or fixed-effects model based on the heterogeneity of the studies. Among the 4,932 studies, 21 were eligible and included in the analysis. The presence of hypoplastic/aplastic A1 was significantly correlated with the formation [OR (95% confidence interval [CI]) = 7.97 (5.58, 11.39), P < 0.001] and rupture [OR (95%CI) = 1.87 (1.29, 2.72), P < 0.001] of AcomA aneurysms. Significant associations between FTP and both the formation [OR (95%CI) = 2.15 (1.41, 3.30), P < 0.001] and rupture [OR (95%CI) = 1.72 (1.26, 2.36), P < 0.001] of PcomA aneurysms were observed.
UNASSIGNED: Significant associations were observed between COW variations and both the formation and rupture of AcomA and PcomA aneurysms. This can help in determining interventions for patients with aneurysms.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=225149, identifier: CRD42021225149.
摘要：
未经证实：前交通动脉（AcomA）和后交通动脉（PcomA）是颅内动脉瘤最常见的两个部位。在AcomA和PcomA动脉瘤患者中经常观察到威利斯环（COW）的解剖变异。需要强有力的证据来确定COW变化对这些动脉瘤的形成和破裂的影响的汇总估计。
UNASSIGNED：本系统综述和荟萃分析旨在利用现有研究确定COW变化对AcomA和PcomA动脉瘤形成和破裂的影响。
未经授权：PubMed，Embase,和WebofScience数据库被系统地搜索了2022年9月21日之前以英语发表的研究。包括调查AcomA动脉瘤和大脑前动脉发育不良/再生障碍性A1段和PcomA动脉瘤以及发育不良/再生障碍性PcomA或胎儿型大脑后动脉（FTP）的研究。使用CochranQ检验和I2统计量评估研究的异质性。根据研究的异质性，使用随机或固定效应模型评估汇总估计值。在4,932项研究中，21人符合条件并纳入分析。发育不良/再生A1的存在与形成显着相关[OR（95％置信区间[CI]）=7.97（5.58，11.39），P<0.001]和破裂[OR（95CI）=1.87（1.29，2.72），AcomA动脉瘤的P<0.001。FTP和两者地层之间的显著关联[OR(95CI)=2.15(1.41，3.30)，P<0.001]和破裂[OR（95CI）=1.72（1.26，2.36），P<0.001]观察到PcomA动脉瘤。
UNASSIGNED：观察到COW变异与AcomA和PcomA动脉瘤的形成和破裂之间存在显著关联。这可以帮助确定对动脉瘤患者的干预措施。
UNASSIGNED：https://www。crd.约克。AC.uk/prospro/display_record.php?RecordID=225149，标识符：CRD42021225149。
UNASSIGNED：本系统综述和荟萃分析旨在利用现有研究确定COW变化对AcomA和PcomA动脉瘤形成和破裂的影响。
未经授权：PubMed，Embase,和WebofScience数据库被系统地搜索了2022年9月21日之前以英语发表的研究。包括调查AcomA动脉瘤和大脑前动脉发育不良/再生障碍性A1段和PcomA动脉瘤以及发育不良/再生障碍性PcomA或胎儿型大脑后动脉（FTP）的研究。使用CochranQ检验和I2统计量评估研究的异质性。根据研究的异质性，使用随机或固定效应模型评估汇总估计值。在4,932项研究中，21人符合条件并纳入分析。发育不良/再生A1的存在与形成显着相关[OR（95％置信区间[CI]）=7.97（5.58，11.39），P<0.001]和破裂[OR（95CI）=1.87（1.29，2.72），AcomA动脉瘤的P<0.001。FTP和两者地层之间的显著关联[OR(95CI)=2.15(1.41，3.30)，P<0.001]和破裂[OR（95CI）=1.72（1.26，2.36），P<0.001]观察到PcomA动脉瘤。
UNASSIGNED：观察到COW变异与AcomA和PcomA动脉瘤的形成和破裂之间存在显著关联。这可以帮助确定对动脉瘤患者的干预措施。
UNASSIGNED：https://www。crd.约克。AC.uk/prospro/display_record.php?RecordID=225149，标识符：CRD42021225149。
