UNASSIGNED: This systematic review and meta-analysis aimed to establish the effect of COW variations on the formation and rupture of AcomA and PcomA aneurysms using available studies.
UNASSIGNED: PubMed, Embase, and Web of Science databases were systematically searched for studies published in English before September 21, 2022. Studies investigating AcomA aneurysms and the hypoplastic/aplastic A1 segment of the anterior cerebral artery and PcomA aneurysms and hypoplastic/aplastic PcomA or fetal-type posterior cerebral artery (FTP) were included. The heterogeneity of the studies was assessed using Cochran Q-test and I2 statistic. Pooled estimate was assessed using either a random- or fixed-effects model based on the heterogeneity of the studies. Among the 4,932 studies, 21 were eligible and included in the analysis. The presence of hypoplastic/aplastic A1 was significantly correlated with the formation [OR (95% confidence interval [CI]) = 7.97 (5.58, 11.39), P < 0.001] and rupture [OR (95%CI) = 1.87 (1.29, 2.72), P < 0.001] of AcomA aneurysms. Significant associations between FTP and both the formation [OR (95%CI) = 2.15 (1.41, 3.30), P < 0.001] and rupture [OR (95%CI) = 1.72 (1.26, 2.36), P < 0.001] of PcomA aneurysms were observed.
UNASSIGNED: Significant associations were observed between COW variations and both the formation and rupture of AcomA and PcomA aneurysms. This can help in determining interventions for patients with aneurysms.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=225149, identifier: CRD42021225149.
UNASSIGNED:本系统综述和荟萃分析旨在利用现有研究确定COW变化对AcomA和PcomA动脉瘤形成和破裂的影响。
未经授权:PubMed,Embase,和WebofScience数据库被系统地搜索了2022年9月21日之前以英语发表的研究。包括调查AcomA动脉瘤和大脑前动脉发育不良/再生障碍性A1段和PcomA动脉瘤以及发育不良/再生障碍性PcomA或胎儿型大脑后动脉(FTP)的研究。使用CochranQ检验和I2统计量评估研究的异质性。根据研究的异质性,使用随机或固定效应模型评估汇总估计值。在4,932项研究中,21人符合条件并纳入分析。发育不良/再生A1的存在与形成显着相关[OR(95%置信区间[CI])=7.97(5.58,11.39),P<0.001]和破裂[OR(95CI)=1.87(1.29,2.72),AcomA动脉瘤的P<0.001。FTP和两者地层之间的显著关联[OR(95CI)=2.15(1.41,3.30),P<0.001]和破裂[OR(95CI)=1.72(1.26,2.36),P<0.001]观察到PcomA动脉瘤。
UNASSIGNED:观察到COW变异与AcomA和PcomA动脉瘤的形成和破裂之间存在显著关联。这可以帮助确定对动脉瘤患者的干预措施。
UNASSIGNED:https://www。crd.约克。AC.uk/prospro/display_record.php?RecordID=225149,标识符:CRD42021225149。