Abstract：
OBJECTIVE: We aimed to identify in-hospital outcomes in young (≤ 65 years) and old (> 65 years) patients after coronary artery bypass grafting (CABG) by analyzing the effect of age on adverse events after on-pump or off-pump CABG.
METHODS: Patients older than 65 years were defined as older patients and others were defined as younger patients. The qualitative data were compared by chi-square or Fisher\'s exact tests. The quantitative data were compared by the two-sample independent t-test or Mann-Whitney U test. Multifactor binary logistic regression was used to control for confounders and to investigate the effect of age on dichotomous outcome variables such as death.
RESULTS: In the on-pump CABG population, the postoperative in-hospital mortality, the incidence of postoperative symptomatic cerebral infarction (POSCI) and postoperative atrial fibrillation (POAF) was higher in older patients than in younger patients (P value < 0.05), and age > 65 years was associated with postoperative in-hospital mortality (OR = 2.370, P value = 0.031), POSCI (OR = 5.033, P value = 0.013), and POAF (OR = 1.499, P value < 0.001). In the off-pump CABG population, the incidence of POAF was higher in older patients than in younger patients (P value < 0.05), and age > 65 years was associated with POAF (OR = 1.392, P value = 0.011).
CONCLUSIONS: In-hospital outcomes after CABG are strongly influenced by age. In on-pump CABG, the risk of postoperative death, POSCI, and POAF was higher in older patients, and in off-pump CABG, the risk of POAF was higher in older patients.
METHODS: Patients older than 65 years were defined as older patients and others were defined as younger patients. The qualitative data were compared by chi-square or Fisher\'s exact tests. The quantitative data were compared by the two-sample independent t-test or Mann-Whitney U test. Multifactor binary logistic regression was used to control for confounders and to investigate the effect of age on dichotomous outcome variables such as death.
RESULTS: In the on-pump CABG population, the postoperative in-hospital mortality, the incidence of postoperative symptomatic cerebral infarction (POSCI) and postoperative atrial fibrillation (POAF) was higher in older patients than in younger patients (P value < 0.05), and age > 65 years was associated with postoperative in-hospital mortality (OR = 2.370, P value = 0.031), POSCI (OR = 5.033, P value = 0.013), and POAF (OR = 1.499, P value < 0.001). In the off-pump CABG population, the incidence of POAF was higher in older patients than in younger patients (P value < 0.05), and age > 65 years was associated with POAF (OR = 1.392, P value = 0.011).
CONCLUSIONS: In-hospital outcomes after CABG are strongly influenced by age. In on-pump CABG, the risk of postoperative death, POSCI, and POAF was higher in older patients, and in off-pump CABG, the risk of POAF was higher in older patients.
摘要：
目的：我们旨在通过分析年龄对冠状动脉旁路移植术（CABG）后不良事件的影响来确定年轻（≤65岁）和老年（>65岁）患者的院内转归。泵或非泵CABG。
方法：65岁以上的患者被定义为老年患者，其他患者被定义为年轻患者。定性数据通过卡方检验或Fisher精确检验进行比较。定量数据采用双样本独立t检验或Mann-WhitneyU检验进行比较。多因素二元逻辑回归用于控制混杂因素，并研究年龄对二分结果变量如死亡的影响。
结果：在泵上CABG人群中，术后院内死亡率，老年患者术后症状性脑梗死(POSCI)和术后心房颤动(POAF)的发生率高于年轻患者(P<0.05),年龄>65岁与术后住院死亡率相关(OR=2.370,P值=0.031),POSCI(OR=5.033,P值=0.013),和POAF(OR=1.499,P值<0.001)。在泵外CABG群体中，老年患者POAF发生率高于年轻患者(P值<0.05),年龄>65岁与POAF相关(OR=1.392,P值=0.011)。
结论：CABG后的住院结局受年龄的影响很大。在泵上CABG中，术后死亡的风险，POSCI，老年患者POAF较高，在泵外CABG中，老年患者发生POAF的风险较高.
方法：65岁以上的患者被定义为老年患者，其他患者被定义为年轻患者。定性数据通过卡方检验或Fisher精确检验进行比较。定量数据采用双样本独立t检验或Mann-WhitneyU检验进行比较。多因素二元逻辑回归用于控制混杂因素，并研究年龄对二分结果变量如死亡的影响。
结果：在泵上CABG人群中，术后院内死亡率，老年患者术后症状性脑梗死(POSCI)和术后心房颤动(POAF)的发生率高于年轻患者(P<0.05),年龄>65岁与术后住院死亡率相关(OR=2.370,P值=0.031),POSCI(OR=5.033,P值=0.013),和POAF(OR=1.499,P值<0.001)。在泵外CABG群体中，老年患者POAF发生率高于年轻患者(P值<0.05),年龄>65岁与POAF相关(OR=1.392,P值=0.011)。
结论：CABG后的住院结局受年龄的影响很大。在泵上CABG中，术后死亡的风险，POSCI，老年患者POAF较高，在泵外CABG中，老年患者发生POAF的风险较高.
