METHODS: This was a retrospective cohort study at a tertiary care academic medical center. All patients that underwent primary surgical resection of OTSCC between 1/1/2015 and 1/1/2022 were reviewed. Patients were identified using the Cerner CoPath Laboratory Information System.
RESULTS: A total of 82 patients met inclusion criteria and were included in the study. Higher grades of WPOI (WPOI 5) were not significantly associated with the presence of ENE in our study (P = 0.82), regardless of the presence of major or minor ENE. WPOI 5 was associated with a higher incidence of local recurrence (P = 0.011).
CONCLUSIONS: Higher grades of WPOI were not found to correlate with the presence of ENE, a common histopathological factor that is used as an important prognostic indicator in OTSCC. It is important for clinicians to consider these factors separately when determining whether a patient is high-risk and would benefit from aggressive multimodal treatment.
方法:这是一项在三级医疗学术中心进行的回顾性队列研究。回顾性分析2015年1月1日至2022年1月1日行OTSCC一期手术切除的患者。使用CernerCoPath实验室信息系统识别患者。
结果:共有82例患者符合纳入标准,被纳入研究。在我们的研究中,较高等级的WPOI(WPOI5)与ENE的存在没有显着相关(P=0.82),无论主要或次要ENE的存在。WPOI5与较高的局部复发发生率相关(P=0.011)。
结论:未发现较高等级的WPOI与ENE的存在相关,一种常见的组织病理学因素,被用作OTSCC的重要预后指标。对于临床医生来说,在确定患者是否具有高风险并将从积极的多模式治疗中受益时,必须分别考虑这些因素。