Abstract：
It has been indicated that calorie restriction (CR) leads to several neuroprotective effects against physiological aging and different neurodegenerative disorders. Unfortunately, the definite therapeutic strategy is not introduced for Multiple sclerosis (MS) as an autoimmune disease of central nervous system (CNS) and researchers are striving to find the best treatment procedures and then optimize them. More recently, several preclinical studies have reported beneficial effects of CR on MS. It was stated that CR can decline demyelination, improve remyelination and decrease neuroinflammation in animal model of MS, as well as reduce body weight and enhance emotional wellbeing in MS patients. In this context we designed this review to examine studies exploring the effects of CR on MS disease based on the clinical and animal models to highlight involved mechanistic implications and future prospective.
摘要：
已经表明，热量限制（CR）会导致几种针对生理衰老和不同神经退行性疾病的神经保护作用。不幸的是,对于作为中枢神经系统(CNS)自身免疫性疾病的多发性硬化(MS),目前还没有采用明确的治疗策略,研究人员正在努力寻找最佳的治疗方法,然后对其进行优化.最近,一些临床前研究报道了CR对MS的有益作用。有人说，CR可以减少脱髓鞘，改善MS动物模型的髓鞘再生和减少神经炎症，以及减轻体重和增强MS患者的情绪健康。在这种情况下，我们设计了这篇综述，以检查基于临床和动物模型探索CR对MS疾病的影响的研究，以强调所涉及的机制含义和未来的前瞻性。
