Abstract：
OBJECTIVE: Vitiligo is an autoimmune skin disorder characterized by circumscribed depigmented macules and patches caused by the loss of functional melanocytes. Although there is no definitive treatment for vitiligo, several treatment options have been associated with relative satisfactory outcomes. The purpose of this study was to compare the efficacy of micro-needling in conjunction with topical 5-fluorouracil (5-FU) versus topical tacrolimus ointment in treating vitiligo patches.
METHODS: This study included nineteen participants, each of whom received both treatments on two randomly selected vitiligo patches of approximately the same size and location. On one patch, a combination of weekly micro-needling and topical application of 5-FU solution was used every other day, while on the other, 0.1% tacrolimus topical ointment was applied twice daily. The G-score was used to compare treatment outcomes after 3 months.
RESULTS: The median duration of the disease in our population was 7 years. Six patients (32%) in the micro-needling plus topical 5-FU treated group showed a moderate to excellent response, indicating a significant improvement between both treatments (p-value = 0.019). In contrast, all other patches treated with topical tacrolimus showed poor improvement. Lower extremity and trunk responded more to treatment with micro-needling plus topical 5-FU than upper extremity and acral areas. Moreover, none of those who have had the disease for more than ten years have responded to treatment. Mild erythema, pinpoint bleeding, and irritation were detected only in the micro-needling treated group.
CONCLUSIONS: The current study showed that using micro-needling in conjunction with 5-FU could treat vitiligo patients more efficiently than tacrolimus monotherapy. Despite showing moderate to excellent improvement in patches treated with micro-needling and 5-FU, this well-tolerated office-based modality still requires additional research.
METHODS: This study included nineteen participants, each of whom received both treatments on two randomly selected vitiligo patches of approximately the same size and location. On one patch, a combination of weekly micro-needling and topical application of 5-FU solution was used every other day, while on the other, 0.1% tacrolimus topical ointment was applied twice daily. The G-score was used to compare treatment outcomes after 3 months.
RESULTS: The median duration of the disease in our population was 7 years. Six patients (32%) in the micro-needling plus topical 5-FU treated group showed a moderate to excellent response, indicating a significant improvement between both treatments (p-value = 0.019). In contrast, all other patches treated with topical tacrolimus showed poor improvement. Lower extremity and trunk responded more to treatment with micro-needling plus topical 5-FU than upper extremity and acral areas. Moreover, none of those who have had the disease for more than ten years have responded to treatment. Mild erythema, pinpoint bleeding, and irritation were detected only in the micro-needling treated group.
CONCLUSIONS: The current study showed that using micro-needling in conjunction with 5-FU could treat vitiligo patients more efficiently than tacrolimus monotherapy. Despite showing moderate to excellent improvement in patches treated with micro-needling and 5-FU, this well-tolerated office-based modality still requires additional research.
摘要：
目的：白癜风是一种自身免疫性皮肤病，其特征是由功能性黑素细胞的丧失引起的局限性去色素斑和斑块。虽然白癜风没有明确的治疗方法，几种治疗方案与相对满意的结局相关.这项研究的目的是比较微针刺结合局部5-氟尿嘧啶（5-FU）与局部他克莫司软膏治疗白癜风贴片的疗效。
方法：这项研究包括19名参与者，每个人都接受了两种随机选择的大小和位置大致相同的白癜风斑块的治疗。在一个补丁上，每周微针刺和局部应用5-FU溶液的组合每隔一天使用一次，而另一方面，每天两次施用0.1%他克莫司局部软膏。使用G评分比较3个月后的治疗结果。
结果：我们人群的中位病程为7年。6名患者（32％）在微针刺加局部5-FU治疗组显示中度至优良的反应，表明两种治疗之间的显着改善（p值=0.019）。相比之下,外用他克莫司治疗的所有其他贴剂均显示改善不良.下肢和躯干对微针加局部5-FU治疗的反应比上肢和肢端区更多。此外，患有这种疾病超过十年的人都没有对治疗有反应。轻度红斑,精确定位出血,仅在微针刺治疗组中检测到刺激。
结论：目前的研究表明，与他克莫司单药治疗相比，使用微针联合5-FU可以更有效地治疗白癜风患者。尽管在微针刺和5-FU处理的贴剂中显示出中等至优异的改善，这种耐受性良好的基于办公室的模式仍然需要额外的研究。
方法：这项研究包括19名参与者，每个人都接受了两种随机选择的大小和位置大致相同的白癜风斑块的治疗。在一个补丁上，每周微针刺和局部应用5-FU溶液的组合每隔一天使用一次，而另一方面，每天两次施用0.1%他克莫司局部软膏。使用G评分比较3个月后的治疗结果。
结果：我们人群的中位病程为7年。6名患者（32％）在微针刺加局部5-FU治疗组显示中度至优良的反应，表明两种治疗之间的显着改善（p值=0.019）。相比之下,外用他克莫司治疗的所有其他贴剂均显示改善不良.下肢和躯干对微针加局部5-FU治疗的反应比上肢和肢端区更多。此外，患有这种疾病超过十年的人都没有对治疗有反应。轻度红斑,精确定位出血,仅在微针刺治疗组中检测到刺激。
结论：目前的研究表明，与他克莫司单药治疗相比，使用微针联合5-FU可以更有效地治疗白癜风患者。尽管在微针刺和5-FU处理的贴剂中显示出中等至优异的改善，这种耐受性良好的基于办公室的模式仍然需要额外的研究。
