METHODS: Patient information was obtained via questionnaire, and a total of 213 PC patients who responded to a questionnaire on defecation problems and their bowel functions were enrolled in this study. We evaluated the constipation, incontinence, and soiling as bowel functions. Univariate and multivariate analyses were performed using a logistic regression analysis to clarify the risk factors for defecation problems.
RESULTS: Of 213 patients with PC, 55 (25.8%) had defecation problems. A multivariate logistic regression analysis showed that sacral agenesis, as an associated anomaly, was significantly associated with defecation problems (odds ratio [OR] 3.19, 95% confidence interval [CI] 1.11-9.16, p = 0.03). The other multivariate logistic regression analysis showed that the PC patients who underwent antegrade continence enema and regularly took laxatives after anorectoplasty had defecation problems (OR 12.4, 95% CI 2.35-65.6, p = 0.003, OR 2.84, 95% CI 1.24-6.55, p = 0.01).
CONCLUSIONS: Sacral agenesis is the potential risk factor of defecation problems in the patients with PC who underwent anorectoplasty. Those patients require vigorous defecation management.
方法:通过问卷调查获得患者信息,本研究纳入了213名接受排便问题和肠道功能调查问卷的PC患者。我们评估了便秘,失禁,并污染肠道功能。使用逻辑回归分析进行单变量和多变量分析,以阐明排便问题的危险因素。
结果:在213例PC患者中,55(25.8%)有排便问题。多因素logistic回归分析显示骶骨发育不全,作为相关的异常,与排便问题显著相关(比值比[OR]3.19,95%置信区间[CI]1.11-9.16,p=0.03)。其他多因素logistic回归分析显示,在肛门直肠成形术后进行顺行失禁灌肠并定期服用泻药的PC患者排便问题(OR12.4,95%CI2.35-65.6,p=0.003,OR2.84,95%CI1.24-6.55,p=0.01)。
结论:骶骨发育不全是接受肛门直肠成形术的PC患者排便问题的潜在危险因素。这些患者需要大力排便管理。