Abstract：
Routine collection of electronic patient-reported outcomes (ePROs) can improve clinical care. However, a low response rate may counteract the benefits. To optimize adoption, the aim of this study was to investigate which patient factors and/or timing of the invitation predicted response to ePROs sent prior to consultations in patients with rheumatoid arthritis. We performed a retrospective database study with clinical data collected as part of usual care from the electronic medical records at Reade Amsterdam. The dataset comprised the email invitations to complete the ePRO sent prior to consultation. Multiple patient factors and factors defining the timing of the invitation were investigated if they predicted response to the ePRO through a multivariable logistic generalized estimating equation analysis. In total, 17.070 ePRO invitations were sent to 3194 patients (mean age 60 (SD 14), 74% female), of which 40% was completed. Patients between 55 and 73 years (OR 1.39, 95%CI 1.09-1.77) and with higher social economic status (SES) (OR 1.51, 95%CI 1.22-1.88) had significantly higher odds for completing the ePRO, while patients living in an urban area had lower odds (OR 0.69, 95% CI 0.62-0.76). In year 4 after implementation, the OR was increased to 3.69 (95% CI 2.91-4.90). The implementation of ePROs in daily clinical practice needs improvement since 40% of the ePROs sent prior to consultations were completed. Patients that had higher odds to report the next ePRO were between the age of 55-73, had a higher socio-economic status, and were residents in a rural area. The adoption of reporting the PRO increased over time, but the timing of the prompt did not predict response. Additional research is needed to understand ePRO completion, especially for patients with lower socio-economic status.
摘要：
常规收集电子患者报告结果（ePR0s）可以改善临床护理。然而,低反应率可能会抵消这些好处。为了优化采用率，这项研究的目的是调查哪些患者因素和/或邀请的时间可以预测类风湿关节炎患者在咨询前对ePROs的反应.我们进行了一项回顾性数据库研究，其中包括从ReadeAmsterdam的电子病历中作为常规护理的一部分收集的临床数据。数据集包括在咨询之前发送的完成ePRO的电子邮件邀请。如果通过多变量逻辑广义估计方程分析预测对ePRO的反应，则研究了多个患者因素和定义邀请时间的因素。总的来说,向3194名患者发送了17.070ePRO邀请（平均年龄60岁（SD14），74%的女性），其中40%已完成。55至73岁（OR1.39，95CI1.09-1.77）和具有较高社会经济地位（SES）（OR1.51，95CI1.22-1.88）的患者完成ePRO的几率明显更高，而生活在城市地区的患者的几率较低(OR0.69,95%CI0.62-0.76).在实施后的第4年，OR增加至3.69(95%CI2.91-4.90)。在日常临床实践中实施ePROs需要改进，因为咨询前发送的ePROs中有40％已完成。报告下一次ePRO的可能性较高的患者年龄在55-73岁之间，具有较高的社会经济地位，是农村地区的居民。报告PRO的采用随着时间的推移而增加，但是提示的时间并不能预测反应。需要额外的研究来理解EPRO的完成，特别是社会经济地位较低的患者。
