PDF(Pubmed)
Abstract：
UNASSIGNED: Telomeres have an essential role in maintaining the integrity and stability of the human chromosomal genome and preserving essential DNA biological functions. Several articles have been published on the association of STL with male semen parameters and clinical pregnancy. The results, however, are either inconclusive or inconsistent. Therefore, this meta-analysis aimed to systematically assess the accuracy and clinical value of sperm telomere length (STL) as a new marker for diagnosing male infertility and predicting the quality of embryonic development.
UNASSIGNED: We performed a comprehensive systematic search for relevant publications in PubMed, the Cochrane Library, Web of Science, Embase, Scopus, and Ovid, from database build to August 2022. All experimental studies exploring the association of STL with male semen quality, male infertility, or embryonic development were included.
UNASSIGNED: Overall, Twelve prospective observational cohort studies (1700 patients) were eligible for inclusion in the meta-analysis. The meta-analysis showed a positive linear correlation between STL and semen parameters. The optimal cut-off value for STL diagnosing male infertility was 1.0, with a sensitivity and specificity of 80%. Regarding STL and embryonic development, the clinical pregnancy rate was associated with longer STL, and there was no significant difference between the two groups regarding fertilization rate.
UNASSIGNED: Our study showed that STL has good diagnostic and predictive value for male fertility and clinical pregnancy and could be used as a new biomarker for diagnosing male infertility and predicting embryonic development.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022303333.
UNASSIGNED: We performed a comprehensive systematic search for relevant publications in PubMed, the Cochrane Library, Web of Science, Embase, Scopus, and Ovid, from database build to August 2022. All experimental studies exploring the association of STL with male semen quality, male infertility, or embryonic development were included.
UNASSIGNED: Overall, Twelve prospective observational cohort studies (1700 patients) were eligible for inclusion in the meta-analysis. The meta-analysis showed a positive linear correlation between STL and semen parameters. The optimal cut-off value for STL diagnosing male infertility was 1.0, with a sensitivity and specificity of 80%. Regarding STL and embryonic development, the clinical pregnancy rate was associated with longer STL, and there was no significant difference between the two groups regarding fertilization rate.
UNASSIGNED: Our study showed that STL has good diagnostic and predictive value for male fertility and clinical pregnancy and could be used as a new biomarker for diagnosing male infertility and predicting embryonic development.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022303333.
摘要：
UNASSIGNED：端粒在维持人类染色体基因组的完整性和稳定性以及保留必需的DNA生物学功能方面具有重要作用。已经发表了几篇关于STL与男性精液参数和临床妊娠的关联的文章。结果，然而,要么不确定，要么不一致。因此,本荟萃分析旨在系统评估精子端粒长度(STL)作为诊断男性不育和预测胚胎发育质量的新指标的准确性和临床价值.
UNASSIGNED：我们对PubMed中的相关出版物进行了全面系统的搜索，Cochrane图书馆,WebofScience,Embase,Scopus,而奥维德,从数据库建设到2022年8月。所有探索STL与男性精液质量关联的实验研究，男性不育,或包括胚胎发育。
未经评估：总的来说，12项前瞻性观察队列研究（1700例患者）符合纳入荟萃分析的条件。Meta分析显示STL与精液参数呈正线性相关。STL诊断男性不育的最佳临界值为1.0，敏感性和特异性为80％。关于STL和胚胎发育，临床妊娠率与更长的STL相关，两组受精率差异无统计学意义。
UASSIGNED：我们的研究表明，STL对男性生育力和临床妊娠具有良好的诊断和预测价值，可作为诊断男性不育和预测胚胎发育的新生物标志物。
UNASSIGNED：https://www。crd.约克。AC.英国/PROSPERO/,标识符CRD42022303333。
UNASSIGNED：我们对PubMed中的相关出版物进行了全面系统的搜索，Cochrane图书馆,WebofScience,Embase,Scopus,而奥维德,从数据库建设到2022年8月。所有探索STL与男性精液质量关联的实验研究，男性不育,或包括胚胎发育。
未经评估：总的来说，12项前瞻性观察队列研究（1700例患者）符合纳入荟萃分析的条件。Meta分析显示STL与精液参数呈正线性相关。STL诊断男性不育的最佳临界值为1.0，敏感性和特异性为80％。关于STL和胚胎发育，临床妊娠率与更长的STL相关，两组受精率差异无统计学意义。
UASSIGNED：我们的研究表明，STL对男性生育力和临床妊娠具有良好的诊断和预测价值，可作为诊断男性不育和预测胚胎发育的新生物标志物。
UNASSIGNED：https://www。crd.约克。AC.英国/PROSPERO/,标识符CRD42022303333。
