PDF(Pubmed)
Abstract：
The beef tapeworm, also known as Taenia saginata, is a zoonotic tapeworm from the genus Taenia in the order Cyclophyllidea. Taenia saginata is a food-borne zoonotic parasite with a worldwide distribution. It poses serious health risks to the host and has a considerable negative socioeconomic impact. Previous studies have explained the population structure of T. saginata within the evolutionary time scale and adaptive evolution. However, it is still unknown how synonymous codons are used by T. saginata. In this study, we used 90 T. saginata strains, applying the codon usage bias (CUB). Both base content and relative synonymous codon usage (RSCU) analysis revealed that AT-ended codons were more frequently used in the genome of T. saginata. Further low CUB was observed from the effective number of codons (ENC) value. The neutrality plot analysis suggested that the dominant factor of natural selection was involved in the structuring of CUB in T. saginata. Further analysis showed that T. saginata has adapted host-specific codon usage patterns to sustain successful replication and transmission chains within hosts (Bos taurus and Homo sapiens). Generally, both natural selection and mutational pressure have an impact on the codon usage patterns of the protein-coding genes in T. saginata. This study is important because it characterized the codon usage pattern in the T. saginata genomes and provided the necessary data for a basic evolutionary study on them.
摘要：
牛肉带虫,也被称为牛带虫,是以Cyclophyllidea为目的牛带虫属的人畜共患tape虫。牛带虫是一种食源性人畜共患寄生虫，分布在世界各地。它对宿主构成严重的健康风险，并具有相当大的负面社会经济影响。先前的研究已经在进化时间尺度和适应性进化范围内解释了木薯的种群结构。然而,尚不清楚T.saginata如何使用同义密码子。在这项研究中,我们用了90个沙吉纳塔菌株,应用密码子使用偏倚（CUB）。碱基含量和相对同义密码子使用（RSCU）分析均显示，AT末端密码子在T.saginata基因组中的使用频率更高。从有效密码子数(ENC)值观察到更低的CUB。中性图分析表明，自然选择的主导因素参与了萨吉纳塔CUB的结构。进一步的分析表明，萨金纳塔已经适应了宿主特异性密码子使用模式，以维持宿主（Bostaurus和Homosapiens）内成功的复制和传播链。一般来说,自然选择和突变压力都会对T.saginata中蛋白质编码基因的密码子使用模式产生影响。这项研究很重要，因为它表征了T.saginata基因组中的密码子使用模式，并为它们的基本进化研究提供了必要的数据。
