PDF(Pubmed)
Abstract：
Dietary micronutrient intakes of iron, folate and vitamin B12 are known to influence hemoglobin. Low maternal hemoglobin (maternal anemia) has been linked to low birthweight and other adverse health outcomes in the fetus and infant. Our primary aim was to explore relationships between maternal dietary micronutrient intakes, maternal full blood count (FBC) parameters and fetal abdominal circumference (AC) and estimated fetal weight (EFW) growth trajectories. Secondarily, we aimed to assess relationships between maternal dietary micronutrient intakes, maternal hemoglobin values and placental weight and birthweight.
Mother-child pairs (n = 759) recruited for the ROLO study were included in this analysis. Maternal dietary micronutrient intakes were calculated from food diaries completed during each trimester of pregnancy. FBC samples were collected at 13- and 28-weeks\' gestation. Fetal ultrasound measurements were recorded at 20- and 34-weeks\' gestation. Growth trajectories for AC and EFW were estimated using latent class trajectory mixture models.
Dietary intakes of iron and folate were deficient for all trimesters. Mean maternal hemoglobin levels were replete at 13- and 28-weeks\' gestation. Dietary iron, folate and vitamin B12 intakes showed no associations with fetal growth trajectories, placental weight or birthweight. Lower maternal hemoglobin concentrations at 28 weeks\' gestation were associated with faster rates of fetal growth and larger placental weights and birthweights.
The negative association between maternal hemoglobin at 28 weeks\' gestation and accelerated fetal and placental growth may be due to greater consumption of maternal iron and hemoglobin by fetuses\' on faster growth trajectories in addition to placental biochemical responses to lower oxygen states.
Mother-child pairs (n = 759) recruited for the ROLO study were included in this analysis. Maternal dietary micronutrient intakes were calculated from food diaries completed during each trimester of pregnancy. FBC samples were collected at 13- and 28-weeks\' gestation. Fetal ultrasound measurements were recorded at 20- and 34-weeks\' gestation. Growth trajectories for AC and EFW were estimated using latent class trajectory mixture models.
Dietary intakes of iron and folate were deficient for all trimesters. Mean maternal hemoglobin levels were replete at 13- and 28-weeks\' gestation. Dietary iron, folate and vitamin B12 intakes showed no associations with fetal growth trajectories, placental weight or birthweight. Lower maternal hemoglobin concentrations at 28 weeks\' gestation were associated with faster rates of fetal growth and larger placental weights and birthweights.
The negative association between maternal hemoglobin at 28 weeks\' gestation and accelerated fetal and placental growth may be due to greater consumption of maternal iron and hemoglobin by fetuses\' on faster growth trajectories in addition to placental biochemical responses to lower oxygen states.
摘要：
目标：膳食微量营养素铁的摄入量，已知叶酸和维生素B12会影响血红蛋白。低母体血红蛋白（母体贫血）与胎儿和婴儿的低出生体重和其他不良健康结果有关。我们的主要目的是探索母亲膳食微量营养素摄入量之间的关系，孕妇全血计数（FBC）参数和胎儿腹围（AC）和估计胎儿体重（EFW）的生长轨迹。其次，我们旨在评估母亲膳食微量营养素摄入量之间的关系，母体血红蛋白值和胎盘重量和出生体重。
方法：纳入ROLO研究的母子对（n=759）纳入分析。从怀孕每个三个月完成的食物日记中计算出母亲的饮食微量营养素摄入量。在妊娠13周和28周收集FBC样本。在妊娠20周和34周记录胎儿超声测量结果。使用潜在类别轨迹混合模型估计AC和EFW的生长轨迹。
结果：所有三个月的饮食中铁和叶酸的摄入量不足。孕妇平均血红蛋白水平在妊娠13周和28周时充足。膳食铁，叶酸和维生素B12的摄入与胎儿生长轨迹无关，胎盘重量或出生体重。妊娠28周时母体血红蛋白浓度较低与胎儿生长速度较快、胎盘重量和出生体重较大有关。
结论：妊娠28周时母体血红蛋白与加速的胎儿和胎盘生长之间的负相关可能是由于胎儿在较快的生长轨迹上消耗了更多的母体铁和血红蛋白，此外还有胎盘对低氧状态的生化反应。
方法：纳入ROLO研究的母子对（n=759）纳入分析。从怀孕每个三个月完成的食物日记中计算出母亲的饮食微量营养素摄入量。在妊娠13周和28周收集FBC样本。在妊娠20周和34周记录胎儿超声测量结果。使用潜在类别轨迹混合模型估计AC和EFW的生长轨迹。
结果：所有三个月的饮食中铁和叶酸的摄入量不足。孕妇平均血红蛋白水平在妊娠13周和28周时充足。膳食铁，叶酸和维生素B12的摄入与胎儿生长轨迹无关，胎盘重量或出生体重。妊娠28周时母体血红蛋白浓度较低与胎儿生长速度较快、胎盘重量和出生体重较大有关。
结论：妊娠28周时母体血红蛋白与加速的胎儿和胎盘生长之间的负相关可能是由于胎儿在较快的生长轨迹上消耗了更多的母体铁和血红蛋白，此外还有胎盘对低氧状态的生化反应。
