Abstract：
Data from a large US population-based, cross-sectional, epidemiological study (the EpiNP Study) were used to assess the symptoms and bother experienced by women with nocturnal polyuria (NP).
Consenting participants recruited from an online panel completed the baseline EpiNP survey online (Lower Urinary Tract Symptoms Tool and urological comorbidities). All reporting ≥2 voids/night and a random sample of 100 respondents, each reporting 0 or 1 void/night were asked to complete a 3-day web-based bladder diary recording time, volume, and urgency rating of each void. NP was calculated by the proportion of urine production that occurred during nocturnal hours using a Nocturnal Polyuria Index (NPI33) threshold of >0.33 or nocturnal urine production of >90 ml/h (NUP90). The frequency of participants reporting LUTS and bother was determined by age and NP: idiopathic NP, NP associated with overactive bladder (NPOAB), NP associated with comorbidities (NPCom), and no NP (did not meet NP criteria).
A total of 5,290 women completed the baseline survey. Mean age (range) was 54.9 (30-95) years; 1,841 (34.8%) reported ≥2 nocturnal voids. The prevalence of LUTS increased across the lifespan; however, bother associated with each LUTS decreased with increasing age. The percentage of women rating bother by nocturia episodes ≥2 \"> somewhat\" ranged from 40.3% to 68.3%, with bother ratings highest in the NPOAB and No NP groups.
NP is prevalent in women with considerable bother and is often associated with other urinary symptoms. Multifactorial causes and potential treatments of NP should be considered, particularly at a later age.
Consenting participants recruited from an online panel completed the baseline EpiNP survey online (Lower Urinary Tract Symptoms Tool and urological comorbidities). All reporting ≥2 voids/night and a random sample of 100 respondents, each reporting 0 or 1 void/night were asked to complete a 3-day web-based bladder diary recording time, volume, and urgency rating of each void. NP was calculated by the proportion of urine production that occurred during nocturnal hours using a Nocturnal Polyuria Index (NPI33) threshold of >0.33 or nocturnal urine production of >90 ml/h (NUP90). The frequency of participants reporting LUTS and bother was determined by age and NP: idiopathic NP, NP associated with overactive bladder (NPOAB), NP associated with comorbidities (NPCom), and no NP (did not meet NP criteria).
A total of 5,290 women completed the baseline survey. Mean age (range) was 54.9 (30-95) years; 1,841 (34.8%) reported ≥2 nocturnal voids. The prevalence of LUTS increased across the lifespan; however, bother associated with each LUTS decreased with increasing age. The percentage of women rating bother by nocturia episodes ≥2 \"> somewhat\" ranged from 40.3% to 68.3%, with bother ratings highest in the NPOAB and No NP groups.
NP is prevalent in women with considerable bother and is often associated with other urinary symptoms. Multifactorial causes and potential treatments of NP should be considered, particularly at a later age.
摘要：
目标：来自美国大量人口的数据，横截面,流行病学研究（EpiNP研究）用于评估夜间多尿（NP）女性的症状和烦恼。
方法：从在线小组招募的同意参与者在线完成了基线EpiNP调查（下尿路症状工具和泌尿系统合并症）。所有报告≥2个空隙/夜，随机抽取100名受访者，每个报告0或1个虚空/晚被要求完成3天的基于网络的膀胱日记记录时间，volume,和每个虚空的紧急评级。使用>0.33的夜间多尿指数（NPI33）阈值或>90ml/h的夜间尿液产生（NUP90），通过夜间小时内发生的尿液产生比例来计算NP。参与者报告LUTS和打扰的频率由年龄和NP决定：特发性NP，NP与膀胱过度活动症（NPOAB）相关，与合并症（NPCom）相关的NP，无NP（不符合NP标准）。
结果：共有5,290名妇女完成了基线调查。平均年龄（范围）为54.9（30-95）岁；1,841（34.8％）报告≥2个夜间空隙。LUTS的患病率在整个生命周期中增加；然而，与每个LUTS相关的麻烦随着年龄的增加而减少。被夜尿症发作≥2“>有点”的女性比例从40.3%到68.3%不等，在NPOAB和NoNP组中，打扰评分最高。
结论：NP在有相当麻烦的女性中普遍存在，并且通常与其他泌尿症状有关。应考虑NP的多因素原因和潜在治疗方法，特别是在以后的年龄。
方法：从在线小组招募的同意参与者在线完成了基线EpiNP调查（下尿路症状工具和泌尿系统合并症）。所有报告≥2个空隙/夜，随机抽取100名受访者，每个报告0或1个虚空/晚被要求完成3天的基于网络的膀胱日记记录时间，volume,和每个虚空的紧急评级。使用>0.33的夜间多尿指数（NPI33）阈值或>90ml/h的夜间尿液产生（NUP90），通过夜间小时内发生的尿液产生比例来计算NP。参与者报告LUTS和打扰的频率由年龄和NP决定：特发性NP，NP与膀胱过度活动症（NPOAB）相关，与合并症（NPCom）相关的NP，无NP（不符合NP标准）。
结果：共有5,290名妇女完成了基线调查。平均年龄（范围）为54.9（30-95）岁；1,841（34.8％）报告≥2个夜间空隙。LUTS的患病率在整个生命周期中增加；然而，与每个LUTS相关的麻烦随着年龄的增加而减少。被夜尿症发作≥2“>有点”的女性比例从40.3%到68.3%不等，在NPOAB和NoNP组中，打扰评分最高。
结论：NP在有相当麻烦的女性中普遍存在，并且通常与其他泌尿症状有关。应考虑NP的多因素原因和潜在治疗方法，特别是在以后的年龄。
