Abstract：
BACKGROUND: The effect of vitamin D status on steatosis has not been fully elucidated. In this study, we planned to investigate this interaction using a large-scale population-based cohort.
METHODS: Patients diagnosed with simple steatosis (K76.0) and non-alcoholic steatohepatitis (NASH) (K75.8) by using the International Classification of Diseases 10th Revision (ICD-10) coding system, and who had 25-hydroxyvitamin D (25OHD) measurements at the diagnosis, were included in the study. Control group comprised subjects without liver diseases. Age, gender, alanine aminotransferase (ALT) and 25OHD levels, and the date of the measurements were recorded.
RESULTS: We compared ALT and 25OHD measurements between the patient and control groups, and between the simple steatosis and NASH subgroups. 25OHD levels were lower and ALT levels were higher in the patient group (p < 0.001, effect size = 0.028, and p < 0.001, effect size = 0.442, respectively). Logistic regression analysis showed that when 25OHD levels decrease by 1 ng/dL, it increases the risk of being in the patient group by 3.7%.
CONCLUSIONS: Our results suggest that vitamin D status may be related to the development of non-alcoholic fatty liver disease (NAFLD). Although this relationship is weak, it may be important in the pathogenesis of steatosis.
METHODS: Patients diagnosed with simple steatosis (K76.0) and non-alcoholic steatohepatitis (NASH) (K75.8) by using the International Classification of Diseases 10th Revision (ICD-10) coding system, and who had 25-hydroxyvitamin D (25OHD) measurements at the diagnosis, were included in the study. Control group comprised subjects without liver diseases. Age, gender, alanine aminotransferase (ALT) and 25OHD levels, and the date of the measurements were recorded.
RESULTS: We compared ALT and 25OHD measurements between the patient and control groups, and between the simple steatosis and NASH subgroups. 25OHD levels were lower and ALT levels were higher in the patient group (p < 0.001, effect size = 0.028, and p < 0.001, effect size = 0.442, respectively). Logistic regression analysis showed that when 25OHD levels decrease by 1 ng/dL, it increases the risk of being in the patient group by 3.7%.
CONCLUSIONS: Our results suggest that vitamin D status may be related to the development of non-alcoholic fatty liver disease (NAFLD). Although this relationship is weak, it may be important in the pathogenesis of steatosis.
摘要：
背景：维生素D状态对脂肪变性的影响尚未完全阐明。在这项研究中,我们计划使用大规模人群队列研究这种交互作用.
方法：使用国际疾病分类第10修订版（ICD-10）编码系统诊断为单纯性脂肪变性（K76.0）和非酒精性脂肪性肝炎（NASH）（K75.8）的患者，在诊断时进行了25-羟基维生素D（25OHD）测量，包括在研究中。对照组包括没有肝脏疾病的受试者。年龄,性别,丙氨酸氨基转移酶（ALT）和25OHD水平，并记录测量日期。
结果：我们比较了患者组和对照组的ALT和25OHD测量值，在单纯脂肪变性和NASH亚组之间。患者组的25OHD水平较低，ALT水平较高（分别为p<0.001，效应大小=0.028和p<0.001，效应大小=0.442）。Logistic回归分析显示，当25OHD水平降低1ng/dL时，它使患者组的风险增加了3.7%。
结论：我们的结果表明，维生素D状态可能与非酒精性脂肪性肝病（NAFLD）的发展有关。虽然这种关系很弱,它可能在脂肪变性的发病机制中很重要。
方法：使用国际疾病分类第10修订版（ICD-10）编码系统诊断为单纯性脂肪变性（K76.0）和非酒精性脂肪性肝炎（NASH）（K75.8）的患者，在诊断时进行了25-羟基维生素D（25OHD）测量，包括在研究中。对照组包括没有肝脏疾病的受试者。年龄,性别,丙氨酸氨基转移酶（ALT）和25OHD水平，并记录测量日期。
结果：我们比较了患者组和对照组的ALT和25OHD测量值，在单纯脂肪变性和NASH亚组之间。患者组的25OHD水平较低，ALT水平较高（分别为p<0.001，效应大小=0.028和p<0.001，效应大小=0.442）。Logistic回归分析显示，当25OHD水平降低1ng/dL时，它使患者组的风险增加了3.7%。
结论：我们的结果表明，维生素D状态可能与非酒精性脂肪性肝病（NAFLD）的发展有关。虽然这种关系很弱,它可能在脂肪变性的发病机制中很重要。
