关键词: Acetylcholinesterase Amygdala Extinction Post-traumatic stress disorder Sex differences

来  源:   DOI:10.4103/1735-5362.359435   PDF(Pubmed)

Abstract:
UNASSIGNED: Men and women show different reactions to trauma and that is believed to be the reason behind the higher prevalence of post-traumatic stress disorder (PTSD) in women. Cholinergic signaling has long been known to be involved in the processing of fear-related information and the amygdala is a critical center for fear modulation. The main goal of the current research was to find (a) whether trauma results in different learning/extinction of fear or spatial-related information among male and female rats and (b) if trauma is associated with different acetylcholinesterase (AchE) activity in the amygdala.
UNASSIGNED: We used single prolonged stress (SPS) as a PTSD model in this study. Normal and SPS animals of both sexes were tested in contextual and spatial tasks (learning and extinction). AchE activity in the amygdala was also measured during each process.
UNASSIGNED: Results indicated that fear and spatial learning were impaired in SPS animals. SPS animals also had deficits in fear and spatial memory extinction and the effect was significantly higher in female- SPS than in the male-SPS group. In the enzymatic tests, AchE activity was increased during the fear extinction test and incremental changes were more significant in the female-SPS group.
UNASSIGNED: Collectively, these findings provided evidence that sex differences in response to trauma were at least partly related to less fear extinction potential in female subjects. It also indicated that the extinction deficit was associated with reduced cholinergic activity in the amygdala of female animals.
摘要:
未经证实:男性和女性对创伤表现出不同的反应,这被认为是女性创伤后应激障碍(PTSD)患病率较高的原因。长期以来,人们一直知道胆碱能信号与恐惧相关信息的处理有关,杏仁核是恐惧调节的关键中心。当前研究的主要目标是发现(a)创伤是否会导致雄性和雌性大鼠之间恐惧或空间相关信息的不同学习/消失,以及(b)创伤是否与杏仁核中不同的乙酰胆碱酯酶(AchE)活性有关。
UNASSIGNED:我们在本研究中使用单一延长应激(SPS)作为PTSD模型。在上下文和空间任务(学习和灭绝)中测试了两种性别的正常和SPS动物。在每个过程中也测量杏仁核中的AchE活性。
UNASSIGNED:结果表明,SPS动物的恐惧和空间学习受到损害。SPS动物在恐惧和空间记忆灭绝方面也有缺陷,雌性SPS的影响明显高于雄性SPS组。在酶学测试中,在恐惧灭绝测试期间,AchE活性增加,雌性SPS组的增量变化更为显着。
未经批准:集体,这些发现提供了证据,表明女性受试者对创伤的反应中的性别差异至少部分与较少的恐惧消退潜力相关.它还表明,灭绝缺陷与雌性动物杏仁核胆碱能活性降低有关。
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