Abstract：
CONCLUSIONS: Spinal cord injury (SCI) represents a serious trauma to the central nervous system. Terahertz (THz) irradiation is an emerging technique, it has potential application prospects in the treatment of central nervous system diseases.
OBJECTIVE: We report on the investigation of the effect and mechanism of THz irradiation in repairing SCI in mice.
METHODS: The effect of THz in SCI was evaluated by the expression of inflammatory factors, the mouse behavioral scale (BMS), and immunofluorescence staining. After RNA sequencing (RNA-seq), we determined the differentially expressed genes (DEGs) and performed GO and KEGG analysis.
RESULTS: After THz irradiation, the inflammatory response, the behavioral function, and the severity of SCI recovered well, indicating that THz irradiation can effectively promote the repair of SCI. GO and KEGG results show that genes related to inflammation, immune regulation, and IL-17 signaling pathway may play an important role in this process.
CONCLUSIONS: THz irradiation can effectively promote the repair of SCI. Genes related to inflammation, immune regulation, and IL-17 signaling pathway may play an important role in this process.
OBJECTIVE: We report on the investigation of the effect and mechanism of THz irradiation in repairing SCI in mice.
METHODS: The effect of THz in SCI was evaluated by the expression of inflammatory factors, the mouse behavioral scale (BMS), and immunofluorescence staining. After RNA sequencing (RNA-seq), we determined the differentially expressed genes (DEGs) and performed GO and KEGG analysis.
RESULTS: After THz irradiation, the inflammatory response, the behavioral function, and the severity of SCI recovered well, indicating that THz irradiation can effectively promote the repair of SCI. GO and KEGG results show that genes related to inflammation, immune regulation, and IL-17 signaling pathway may play an important role in this process.
CONCLUSIONS: THz irradiation can effectively promote the repair of SCI. Genes related to inflammation, immune regulation, and IL-17 signaling pathway may play an important role in this process.
摘要：
结论：脊髓损伤（SCI）代表中枢神经系统的严重创伤。太赫兹(THz)辐照技术是一种新兴的,在治疗中枢神经系统疾病方面具有潜在的应用前景。
目的：我们报道了THz照射在小鼠脊髓损伤修复中的作用和机制。
方法：通过炎症因子的表达来评价THz在SCI中的作用。小鼠行为量表(BMS)，和免疫荧光染色。RNA测序（RNA-seq）后，我们确定了差异表达基因（DEGs）并进行了GO和KEGG分析。
结果：THz辐照后，炎症反应，行为功能，SCI的严重程度恢复良好，说明THz辐照能有效促进SCI的修复。GO和KEGG结果显示，与炎症相关的基因，免疫调节，IL-17信号通路可能在此过程中发挥重要作用。
结论：THz照射可有效促进SCI修复。与炎症相关的基因，免疫调节，IL-17信号通路可能在此过程中发挥重要作用。
目的：我们报道了THz照射在小鼠脊髓损伤修复中的作用和机制。
方法：通过炎症因子的表达来评价THz在SCI中的作用。小鼠行为量表(BMS)，和免疫荧光染色。RNA测序（RNA-seq）后，我们确定了差异表达基因（DEGs）并进行了GO和KEGG分析。
结果：THz辐照后，炎症反应，行为功能，SCI的严重程度恢复良好，说明THz辐照能有效促进SCI的修复。GO和KEGG结果显示，与炎症相关的基因，免疫调节，IL-17信号通路可能在此过程中发挥重要作用。
结论：THz照射可有效促进SCI修复。与炎症相关的基因，免疫调节，IL-17信号通路可能在此过程中发挥重要作用。
