Abstract：
This study investigated the compliance with a guideline-based antibiotic regimen on the outcome of patients surgically treated for a fracture-related infection (FRI).
In this international multicenter observational study, patients were included when diagnosed with an FRI between 2015 and 2019. FRI was defined according to the FRI consensus definition. All patients were followed for at least one year. The chosen antibiotic regimens were compared to the published guidelines from the FRI Consensus Group and correlated to outcome. Treatment success was defined as the eradication of infection with limb preservation.
A total of 433 patients (mean age 49.7 ± 16.1 years) with FRIs of mostly the tibia (50.6%) and femur (21.7%) were included. Full compliance of the antibiotic regime to the published guidelines was observed in 107 (24.7%) cases. Non-compliance was mostly due to deviations from the recommended dosing, followed by the administration of an alternative antibiotic than the one recommended or an incorrect use or non-use of rifampin. Non-compliance was not associated with a worse outcome: treatment failure was 12.1% in compliant versus 13.2% in non-compliant cases (p = 0.87).
We report good outcomes in the treatment of FRI and demonstrated that minor deviations from the FRI guideline are not associated with poorer outcomes.
In this international multicenter observational study, patients were included when diagnosed with an FRI between 2015 and 2019. FRI was defined according to the FRI consensus definition. All patients were followed for at least one year. The chosen antibiotic regimens were compared to the published guidelines from the FRI Consensus Group and correlated to outcome. Treatment success was defined as the eradication of infection with limb preservation.
A total of 433 patients (mean age 49.7 ± 16.1 years) with FRIs of mostly the tibia (50.6%) and femur (21.7%) were included. Full compliance of the antibiotic regime to the published guidelines was observed in 107 (24.7%) cases. Non-compliance was mostly due to deviations from the recommended dosing, followed by the administration of an alternative antibiotic than the one recommended or an incorrect use or non-use of rifampin. Non-compliance was not associated with a worse outcome: treatment failure was 12.1% in compliant versus 13.2% in non-compliant cases (p = 0.87).
We report good outcomes in the treatment of FRI and demonstrated that minor deviations from the FRI guideline are not associated with poorer outcomes.
摘要：
目的：本研究调查了骨折相关性感染（FRI）手术治疗患者对基于指南的抗生素治疗方案的依从性。
方法：在这项国际多中心观察研究中，在2015年至2019年期间被诊断为FRI的患者被纳入.FRI根据FRI共识定义。所有患者随访至少一年。将选择的抗生素方案与FRI共识小组公布的指南进行比较，并与结果相关。治疗成功定义为根除感染并保留肢体。
结果：共包括433例患者（平均年龄49.7±16.1岁），其中FRI主要为胫骨（50.6%）和股骨（21.7%）。在107例（24.7％）病例中观察到抗生素方案完全遵守已发布的指南。不合规主要是由于偏离推荐剂量，然后给予推荐的替代抗生素或不正确使用或不使用利福平。不依从性与较差的结果无关：依从性病例的治疗失败为12.1%，而非依从性病例为13.2%（p=0.87）。
结论：我们报告了FRI治疗的良好结果，并表明与FRI指南的微小偏差与较差的结果无关。
方法：在这项国际多中心观察研究中，在2015年至2019年期间被诊断为FRI的患者被纳入.FRI根据FRI共识定义。所有患者随访至少一年。将选择的抗生素方案与FRI共识小组公布的指南进行比较，并与结果相关。治疗成功定义为根除感染并保留肢体。
结果：共包括433例患者（平均年龄49.7±16.1岁），其中FRI主要为胫骨（50.6%）和股骨（21.7%）。在107例（24.7％）病例中观察到抗生素方案完全遵守已发布的指南。不合规主要是由于偏离推荐剂量，然后给予推荐的替代抗生素或不正确使用或不使用利福平。不依从性与较差的结果无关：依从性病例的治疗失败为12.1%，而非依从性病例为13.2%（p=0.87）。
结论：我们报告了FRI治疗的良好结果，并表明与FRI指南的微小偏差与较差的结果无关。
