Abstract：
Objective: We developed an Excel-based cost calculator to assess the economic burden of university-based Neisseria meningitidis serogroup B (MenB) outbreaks. Participants: Hypothetical university with 6,354 students. Methods: Total societal costs of outbreak were estimated for three MenB pre-matriculation immunization policies-vaccination required, vaccination recommended, and no vaccine policy-under three different cost assumptions (low/mid-range/high cost). Results: Mid-range cost estimates of an outbreak under \"no policy\" were $2.60 and $2.70 million (of which 35% were incurred by the university) if targeting all undergraduates for mass vaccination with a two-/three-dose vaccine, respectively. The \"required\" and \"recommended\" policies lowered the burden to $2.17-$2.18 million and $2.34-$2.39 million, respectively. For a larger university with 40,000 students, costs were almost $9 million for a two-dose vaccine with \"no policy\" in place. Conclusions: The economic burden of a university MenB outbreak is substantial, but could be mitigated by a pre-matriculation MenB vaccination requirement or recommendation.
摘要：
目标：我们开发了一种基于Excel的成本计算器，以评估基于大学的脑膜炎奈瑟菌血清群B（MenB）暴发的经济负担。参与者：假设大学，有6,354名学生。方法：估计了三种MenB预科免疫政策-所需的疫苗接种，推荐接种疫苗,和无疫苗政策-在三个不同的成本假设下（低/中/高成本）。结果：如果针对所有本科生进行两次/三次疫苗的大规模疫苗接种，“无政策”下爆发的中期成本估计分别为2.6美元和270万美元（其中35％由大学产生），分别。“要求”和“建议”政策将负担降低到2.17-218万美元和2.34-239万美元，分别。对于拥有40,000名学生的大型大学来说，在“没有政策”的情况下，两剂疫苗的成本接近900万美元。结论：大学MenB爆发的经济负担是巨大的，但可以通过预科MenB疫苗接种要求或推荐来缓解.
