Abstract：
Kidney transplant recipients (KTRs) represent a vulnerable group of patients who develop a number of comorbidities. Severe periodontitis (SP) is associated with the most common chronic systemic diseases including kidney diseases. The objective of this study was to explore the risk factors for SP in KTRs.
In this study, KTRs were divided into those with or without periodontitis and in relation to the severity of periodontitis. A comprehensive medical and periodontal examination was performed and evaluated. Multivariate logistic regression was performed to examine possible risk factors for SP among KTRs.
A total of 100 KTRs were included in the analysis, of which 87% had periodontitis. Significant predictors of periodontitis were older age (OR = 1.07, 95% CI [1.01, 1.13], p = 0.016) and lower skeletal muscle mass (OR = 0.88, 95% CI [0.78, 0.99], p = 0.035). When examining periodontitis severity, predictors of SP (n = 21, 24%) were increased levels of uric acid (OR = 1.01, 95% CI [1.00, 1.02], p = 0.022) and dental plaque (OR = 1.04, 95% CI [1.01, 1.07], p = 0.013). In the subset analysis that included only KTRs with measured advanced glycation end products (AGE) (n = 47), 34% (n = 16) had SP. The predictors of SP were AGE (OR = 3.89, 95% CI [1.28, 11.82], p = 0.017) and dental plaque (OR = 1.07, 95% CI [1.01, 1.13], p = 0.028).
KTRs with SP had significantly higher uric acid levels and AGE, which may contribute to the systemic health status of this patient population.
In this study, KTRs were divided into those with or without periodontitis and in relation to the severity of periodontitis. A comprehensive medical and periodontal examination was performed and evaluated. Multivariate logistic regression was performed to examine possible risk factors for SP among KTRs.
A total of 100 KTRs were included in the analysis, of which 87% had periodontitis. Significant predictors of periodontitis were older age (OR = 1.07, 95% CI [1.01, 1.13], p = 0.016) and lower skeletal muscle mass (OR = 0.88, 95% CI [0.78, 0.99], p = 0.035). When examining periodontitis severity, predictors of SP (n = 21, 24%) were increased levels of uric acid (OR = 1.01, 95% CI [1.00, 1.02], p = 0.022) and dental plaque (OR = 1.04, 95% CI [1.01, 1.07], p = 0.013). In the subset analysis that included only KTRs with measured advanced glycation end products (AGE) (n = 47), 34% (n = 16) had SP. The predictors of SP were AGE (OR = 3.89, 95% CI [1.28, 11.82], p = 0.017) and dental plaque (OR = 1.07, 95% CI [1.01, 1.13], p = 0.028).
KTRs with SP had significantly higher uric acid levels and AGE, which may contribute to the systemic health status of this patient population.
摘要：
背景：肾移植受者（KTRs）是一组易受伤害的患者，他们会出现多种合并症。严重牙周炎（SP）与最常见的慢性全身性疾病（包括肾脏疾病）有关。本研究的目的是探讨KTRs中SP的危险因素。
方法：在本研究中，KTRs分为有或没有牙周炎以及与牙周炎严重程度有关的那些。进行了全面的医学和牙周检查并进行了评估。采用多因素logistic回归分析KTRs中SP的可能危险因素。
结果：总共100KTRs被纳入分析，其中87%患有牙周炎。牙周炎的重要预测因素是年龄较大（OR（95％CI）=1.07（1.01-1.13），P=0.016）和较低的骨骼肌质量（OR（95％CI）=0.88（0.78-0.99），P=0.035)。检查牙周炎严重程度时，SP的预测因子（n=21，24％）是尿酸水平升高（OR（95％CI）=1.01（1.00-1.02），P=0.022)和牙菌斑(OR(95%CI)=1.04(1.01-1.07)，P=0.013)。在子集分析中，仅包括具有测量的晚期糖基化终产物（AGE）的KTRs（n=47），34%(n=16)有SP。SP的预测因素是年龄(OR(95%CI)=3.89(1.28-11.82)，P=0.017)和牙菌斑(OR(95%CI)=1.07(1.01-1.13)，P=0.028)。
结论：KTRs伴SP有明显较高的尿酸水平和AGE,这可能有助于该患者人群的全身健康状况。本文受版权保护。保留所有权利。
方法：在本研究中，KTRs分为有或没有牙周炎以及与牙周炎严重程度有关的那些。进行了全面的医学和牙周检查并进行了评估。采用多因素logistic回归分析KTRs中SP的可能危险因素。
结果：总共100KTRs被纳入分析，其中87%患有牙周炎。牙周炎的重要预测因素是年龄较大（OR（95％CI）=1.07（1.01-1.13），P=0.016）和较低的骨骼肌质量（OR（95％CI）=0.88（0.78-0.99），P=0.035)。检查牙周炎严重程度时，SP的预测因子（n=21，24％）是尿酸水平升高（OR（95％CI）=1.01（1.00-1.02），P=0.022)和牙菌斑(OR(95%CI)=1.04(1.01-1.07)，P=0.013)。在子集分析中，仅包括具有测量的晚期糖基化终产物（AGE）的KTRs（n=47），34%(n=16)有SP。SP的预测因素是年龄(OR(95%CI)=3.89(1.28-11.82)，P=0.017)和牙菌斑(OR(95%CI)=1.07(1.01-1.13)，P=0.028)。
结论：KTRs伴SP有明显较高的尿酸水平和AGE,这可能有助于该患者人群的全身健康状况。本文受版权保护。保留所有权利。
