PDF(Pubmed)
Abstract：
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a subtype of non-Hodgkin lymphoma (NHL) that is localized to the skin. Disseminated disease is rare, and visceral organ involvement is even more so. We report a unique case of PCALCL with gastric metastasis. A 75-year-old man with a history of cutaneous left lower extremity PCALCL status post radiation therapy initially presented with abdominal pain and was found to have diffuse celiac axis and retroperitoneal lymphadenopathy. Endoscopy, initially done to biopsy an involved lymph node (LN), demonstrated a friable gastric nodular lesion with telangiectasias. Biopsy of the lesion and LN revealed anaplastic large cell lymphoma, identical in pathology to the known skin lesion. The patient was treated with systemic chemotherapy with a good response. PCALCL has been thought of as a localized malignancy with a good prognosis and low potential for extracutaneous spread. To our knowledge, this is the first instance of metastatic PCALCL involving the stomach.
摘要：
原发性皮肤间变性大细胞淋巴瘤（PCALCL）是非霍奇金淋巴瘤（NHL）的一种亚型，定位于皮肤。播散性疾病很少见，内脏器官受累更是如此。我们报告了一例PCALCL伴胃转移的独特病例。一名75岁的男性，有放疗后皮肤左下肢PCALCL状态的病史，最初表现为腹痛，并被发现有弥漫性腹腔轴和腹膜后淋巴结病。内窥镜检查,最初进行活检受累淋巴结（LN），表现为脆弱的胃结节状病变并伴有毛细血管扩张。病变和LN活检显示间变性大细胞淋巴瘤，病理与已知皮肤病变相同。患者接受全身化疗，反应良好。PCALCL被认为是一种局部恶性肿瘤，预后良好，皮外扩散可能性低。据我们所知,这是首例累及胃的转移性PCALCL.
