PDF(Pubmed)
Abstract：
UNASSIGNED: Paraneoplastic peripheral neuropathy (PPN) caused by olfactory neuroblastoma (ONB) has not yet been reported.
UNASSIGNED: We present a rare case of an adult who hospitalized repeatedly over the past 9 months for persistent pain and numbness in the limbs. This patient was initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and treated accordingly, but neurological symptoms did not improve significantly. After this admission, FDG-PET/CT showed focal hypermetabolism of a soft-tissue mass in the nasal cavity, and further lesion biopsy suggested ONB. Combined with positive serum anti-Hu antibody, the diagnosis of PPN associated with ONB was eventually made. Furthermore, the patient\'s neurological symptoms were relieved after removal of the primary tumor, confirming the accuracy of the diagnosis.
UNASSIGNED: Our case not only expanded the clinical characteristics of ONB but also highlighted the importance of early and comprehensive tumor screening for the diagnosis of PPN.
UNASSIGNED: We present a rare case of an adult who hospitalized repeatedly over the past 9 months for persistent pain and numbness in the limbs. This patient was initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and treated accordingly, but neurological symptoms did not improve significantly. After this admission, FDG-PET/CT showed focal hypermetabolism of a soft-tissue mass in the nasal cavity, and further lesion biopsy suggested ONB. Combined with positive serum anti-Hu antibody, the diagnosis of PPN associated with ONB was eventually made. Furthermore, the patient\'s neurological symptoms were relieved after removal of the primary tumor, confirming the accuracy of the diagnosis.
UNASSIGNED: Our case not only expanded the clinical characteristics of ONB but also highlighted the importance of early and comprehensive tumor screening for the diagnosis of PPN.
摘要：
未经证实：由嗅神经母细胞瘤（ONB）引起的副肿瘤周围神经病（PPN）尚未报道。
未经评估：我们介绍了一例罕见的成人病例，在过去的9个月里，他因四肢持续疼痛和麻木而反复住院。该患者最初被诊断为慢性炎症性脱髓鞘性多发性神经病（CIDP），并进行了相应的治疗。但神经症状没有明显改善。在这次录取之后,FDG-PET/CT显示鼻腔软组织肿块的局灶性高代谢，进一步病变活检提示ONB。结合血清抗Hu抗体阳性，最终诊断为PPN与ONB相关。此外，切除原发肿瘤后，患者的神经症状得到缓解，确认诊断的准确性。
UNASSIGNED：我们的病例不仅扩展了ONB的临床特征，而且强调了早期和全面的肿瘤筛查对PPN诊断的重要性。
未经评估：我们介绍了一例罕见的成人病例，在过去的9个月里，他因四肢持续疼痛和麻木而反复住院。该患者最初被诊断为慢性炎症性脱髓鞘性多发性神经病（CIDP），并进行了相应的治疗。但神经症状没有明显改善。在这次录取之后,FDG-PET/CT显示鼻腔软组织肿块的局灶性高代谢，进一步病变活检提示ONB。结合血清抗Hu抗体阳性，最终诊断为PPN与ONB相关。此外，切除原发肿瘤后，患者的神经症状得到缓解，确认诊断的准确性。
UNASSIGNED：我们的病例不仅扩展了ONB的临床特征，而且强调了早期和全面的肿瘤筛查对PPN诊断的重要性。
