PDF(Pubmed)
Abstract：
UNASSIGNED: Mild behavioral impairment (MBI) is a syndrome that uses later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a group at high risk for incident dementia. MBI is associated with neurodegenerative disease markers in advance of syndromic dementia. Functional connectivity (FC) correlates of MBI are understudied and could provide further insights into mechanisms early in the disease course. We used resting-state functional magnetic resonance imaging (rs-fMRI) to test the hypothesis that FC within the default mode network (DMN) and salience network (SN) of persons with MBI (MBI+) is reduced, relative to those without (MBI-).
UNASSIGNED: From two harmonized dementia-free cohort studies, using a score of ≥6 on the MBI Checklist to define MBI status, 32 MBI+ and 63 MBI- individuals were identified (mean age: 71.7 years; 54.7% female). Seed-based connectivity analysis was implemented in each MBI group using the CONN fMRI toolbox (v20.b), with the posterior cingulate cortex (PCC) as the seed region within the DMN and anterior cingulate cortex (ACC) as the seed within the SN. The average time series from the PCC and ACC were used to determine FC with other regions within the DMN (medial prefrontal cortex, lateral inferior parietal cortex) and SN (anterior insula, supramarginal gyrus, rostral prefrontal cortex), respectively. Age, sex, years of education, and Montreal Cognitive Assessment scores were included as model covariates. The false discovery rate approach was used to correct for multiple comparisons, with a p-value of .05 considered significant.
UNASSIGNED: For the DMN, MBI+ individuals exhibited reduced FC between the PCC and the medial prefrontal cortex, compared to MBI-. For the SN, MBI+ individuals exhibited reduced FC between the ACC and left anterior insula.
UNASSIGNED: MBI in dementia-free older adults is associated with reduced FC in networks known to be disrupted in dementia. Our results complement the evidence linking MBI with Alzheimer\'s disease biomarkers.
UNASSIGNED: Resting-state functional magnetic resonance imaging was completed in 95 dementia-free persons from FAVR and COMPASS-ND studies.Participants were stratified by informant-rated Mild Behavioral Impairment Checklist (MBI-C) score, ≥6 for MBI+.MBI+ participants showed reduced functional connectivity (FC) within the default mode network and salience network.These FC changes are consistent with those seen in early-stage Alzheimer\'s disease.MBI may help identify persons with early-stage neurodegenerative disease.
UNASSIGNED: From two harmonized dementia-free cohort studies, using a score of ≥6 on the MBI Checklist to define MBI status, 32 MBI+ and 63 MBI- individuals were identified (mean age: 71.7 years; 54.7% female). Seed-based connectivity analysis was implemented in each MBI group using the CONN fMRI toolbox (v20.b), with the posterior cingulate cortex (PCC) as the seed region within the DMN and anterior cingulate cortex (ACC) as the seed within the SN. The average time series from the PCC and ACC were used to determine FC with other regions within the DMN (medial prefrontal cortex, lateral inferior parietal cortex) and SN (anterior insula, supramarginal gyrus, rostral prefrontal cortex), respectively. Age, sex, years of education, and Montreal Cognitive Assessment scores were included as model covariates. The false discovery rate approach was used to correct for multiple comparisons, with a p-value of .05 considered significant.
UNASSIGNED: For the DMN, MBI+ individuals exhibited reduced FC between the PCC and the medial prefrontal cortex, compared to MBI-. For the SN, MBI+ individuals exhibited reduced FC between the ACC and left anterior insula.
UNASSIGNED: MBI in dementia-free older adults is associated with reduced FC in networks known to be disrupted in dementia. Our results complement the evidence linking MBI with Alzheimer\'s disease biomarkers.
UNASSIGNED: Resting-state functional magnetic resonance imaging was completed in 95 dementia-free persons from FAVR and COMPASS-ND studies.Participants were stratified by informant-rated Mild Behavioral Impairment Checklist (MBI-C) score, ≥6 for MBI+.MBI+ participants showed reduced functional connectivity (FC) within the default mode network and salience network.These FC changes are consistent with those seen in early-stage Alzheimer\'s disease.MBI may help identify persons with early-stage neurodegenerative disease.
摘要：
未经证实：轻度行为障碍（MBI）是一种综合征，它利用晚年出现的和持续的神经精神症状（NPS）来确定一个处于痴呆事件高风险的群体。MBI与综合征性痴呆之前的神经退行性疾病标志物相关。MBI的功能连接（FC）相关性研究不足，可以在疾病过程早期提供对机制的进一步见解。我们使用静息状态功能磁共振成像（rs-fMRI）来检验以下假设：MBI（MBI）患者的默认模式网络（DMN）和显着性网络（SN）内的FC减少，相对于那些没有（MBI-）。
未经评估：根据两项协调的无痴呆队列研究，使用MBI清单上的≥6分定义MBI状态，确定了32个MBI+和63个MBI-个体(平均年龄:71.7岁;54.7%为女性)。使用CONNfMRI工具箱（v20。)后扣带皮层（PCC）作为DMN内的种子区域，前扣带皮层（ACC）作为SN内的种子。PCC和ACC的平均时间序列用于确定DMN内其他区域的FC（内侧前额叶皮质，外侧下顶叶皮质）和SN（前岛，颈上回，前额叶皮质)，分别。年龄,性别,多年的教育，和蒙特利尔认知评估评分作为模型协变量。错误发现率方法用于校正多重比较，p值为0.05被认为是显著的。
未经评估：对于DMN，MBI+个体在PCC和内侧前额叶皮层之间表现出减少的FC，与MBI相比。对于SN，MBI+个体在ACC和左前脑岛之间表现出降低的FC。
未经证实：无痴呆老年人的MBI与已知在痴呆症中被破坏的网络中的FC降低有关。我们的结果补充了将MBI与阿尔茨海默病生物标志物联系起来的证据。
UNASSIGNED：在FAVR和COMPASS-ND研究的95名无痴呆患者中完成了静息状态功能磁共振成像。参与者通过信息评级的轻度行为损害清单（MBI-C）评分进行分层，MBI+≥6。MBI参与者在默认模式网络和显着性网络中显示出减少的功能连接（FC）。这些FC变化与早期阿尔茨海默病的变化一致。MBI可以帮助识别患有早期神经退行性疾病的人。
未经评估：根据两项协调的无痴呆队列研究，使用MBI清单上的≥6分定义MBI状态，确定了32个MBI+和63个MBI-个体(平均年龄:71.7岁;54.7%为女性)。使用CONNfMRI工具箱（v20。)后扣带皮层（PCC）作为DMN内的种子区域，前扣带皮层（ACC）作为SN内的种子。PCC和ACC的平均时间序列用于确定DMN内其他区域的FC（内侧前额叶皮质，外侧下顶叶皮质）和SN（前岛，颈上回，前额叶皮质)，分别。年龄,性别,多年的教育，和蒙特利尔认知评估评分作为模型协变量。错误发现率方法用于校正多重比较，p值为0.05被认为是显著的。
未经评估：对于DMN，MBI+个体在PCC和内侧前额叶皮层之间表现出减少的FC，与MBI相比。对于SN，MBI+个体在ACC和左前脑岛之间表现出降低的FC。
未经证实：无痴呆老年人的MBI与已知在痴呆症中被破坏的网络中的FC降低有关。我们的结果补充了将MBI与阿尔茨海默病生物标志物联系起来的证据。
UNASSIGNED：在FAVR和COMPASS-ND研究的95名无痴呆患者中完成了静息状态功能磁共振成像。参与者通过信息评级的轻度行为损害清单（MBI-C）评分进行分层，MBI+≥6。MBI参与者在默认模式网络和显着性网络中显示出减少的功能连接（FC）。这些FC变化与早期阿尔茨海默病的变化一致。MBI可以帮助识别患有早期神经退行性疾病的人。
