PDF(Pubmed)
Abstract：
Growing evidence points to a spectrum of non-motor symptoms, including cognitive difficulties that have a greater impact on functional outcomes and quality of life than motor symptoms in cervical dystonia (CD). Some cognitive impairments have been reported; however, findings are inconsistent, and described across mixed groups of dystonia. The current review aimed to examine the evidence for cognitive impairments in CD. MEDLINE, EMBASE, PsychINFO and Web of Science databases were searched. Studies were included if they met the following criteria (i) cross-sectional or longitudinal studies of adults with CD, (ii) where the results of standardised measures of cognitive or neuropsychological function in any form were assessed and reported, (iii) results compared to a control group or normative data, and (iv) were published in English. Results are presented in a narrative synthesis. Twenty studies were included. Subtle difficulties with general intellectual functioning, processing speed, verbal memory, visual memory, visuospatial function, executive function, and social cognition were identified while language, and attention and working memory appear to be relatively spared. Several methodological limitations were identified that should be considered when interpreting the evidence to describe a specific profile of cognitive impairment in CD. Clinical and research implications are discussed.
摘要：
越来越多的证据指出一系列非运动症状，包括认知困难，对功能结局和生活质量的影响大于对宫颈肌张力障碍（CD）运动症状的影响。已经报道了一些认知障碍；然而，调查结果不一致，并描述了肌张力障碍的混合组。当前的评论旨在检查CD中认知障碍的证据。MEDLINE,EMBASE,搜索了PsychINFO和WebofScience数据库。如果符合以下标准，则纳入研究（i）成人CD的横断面或纵向研究，（ii）评估和报告了任何形式的认知或神经心理功能标准化措施的结果，（iii）与对照组或规范数据相比的结果，和(四)以英文出版。结果以叙事综合形式呈现。包括20项研究。一般智力功能的微妙困难，处理速度,口头记忆,视觉记忆,视觉空间功能，执行功能，和社会认知被识别，而语言，注意力和工作记忆似乎相对幸免。确定了一些方法上的局限性，在解释证据以描述CD中认知障碍的特定特征时应考虑这些局限性。讨论了临床和研究意义。
