Abstract:
Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.
摘要:
毛细管电泳(CE)越来越多地用于筛查血红蛋白病。我们在这里报告了由CE确定的中国流行的血红蛋白(Hb)变体的迁移位置。CE迁移位置显示出优异的精度和较小的个体间差异。我们得出的结论是,CE迁移位置可以用作鉴定Hb变体的可靠指标,并且还可以帮助建立一个特征良好的Hb变体文库,以进行精细的推定鉴定。