PDF(Pubmed)
Abstract：
UNASSIGNED: The ABO gene locus has been identified to be associated with myocardial infarction in patients with coronary heart disease. The primary focus of this hospital-based study was to explore the relationship of ABO blood groups and ABO genotypes with acute myocardial infarction (AMI) in Karachi, Pakistan.
UNASSIGNED: In a comparative cross-sectional study, an equal number of adult AMI patients and healthy controls (n=275 in each group; age range 30-70 years, both males and females) were recruited from the Aga Khan University and NICVD, Karachi, with informed consent. The blood samples were analyzed for ABO blood groups and other biomarkers. PCR followed by RFLP techniques were employed for determining the ABO genotypes. Multinomial regression was used to evaluate the association of genotypes with the risk of AMI.
UNASSIGNED: Thirteen different combinations of ABO genotypes were observed while the O2O2 and A2A2 genotypes were not detected. No significant association based on the distribution of blood groups A, B, O and AB among AMI patients and healthy individuals was observed. The odds of AMI were 3.32 times in subjects with BB genotype as compared to subjects with OO genotypes after adjustment of age, gender, body mass index, heart rate, total cholesterol, and waist circumference [AOR (95% CI) =3.32 (1.36-8.08), p-value =0.008].
UNASSIGNED: Our hospital-based study indicates that ABO genotype BB was significantly associated with the risk of AMI. This harmful effect of the BB genotype could have a possible relationship with AMI\'s development in the Pakistani population.
UNASSIGNED: In a comparative cross-sectional study, an equal number of adult AMI patients and healthy controls (n=275 in each group; age range 30-70 years, both males and females) were recruited from the Aga Khan University and NICVD, Karachi, with informed consent. The blood samples were analyzed for ABO blood groups and other biomarkers. PCR followed by RFLP techniques were employed for determining the ABO genotypes. Multinomial regression was used to evaluate the association of genotypes with the risk of AMI.
UNASSIGNED: Thirteen different combinations of ABO genotypes were observed while the O2O2 and A2A2 genotypes were not detected. No significant association based on the distribution of blood groups A, B, O and AB among AMI patients and healthy individuals was observed. The odds of AMI were 3.32 times in subjects with BB genotype as compared to subjects with OO genotypes after adjustment of age, gender, body mass index, heart rate, total cholesterol, and waist circumference [AOR (95% CI) =3.32 (1.36-8.08), p-value =0.008].
UNASSIGNED: Our hospital-based study indicates that ABO genotype BB was significantly associated with the risk of AMI. This harmful effect of the BB genotype could have a possible relationship with AMI\'s development in the Pakistani population.
摘要：
未经证实：已鉴定ABO基因位点与冠心病患者的心肌梗死有关。这项以医院为基础的研究的主要重点是探讨卡拉奇的ABO血型和ABO基因型与急性心肌梗死（AMI）的关系。巴基斯坦。
未经评估：在一项比较的横断面研究中，相同数量的成人AMI患者和健康对照（每组n=275；年龄范围30-70岁，男性和女性）都是从阿加汗大学和NICVD招募的，卡拉奇,知情同意。分析血液样品的ABO血型和其他生物标志物。采用PCR和RFLP技术确定ABO基因型。多项回归用于评估基因型与AMI风险的关联。
UNASSIGNED：观察到13种不同的ABO基因型组合，而未检测到O2O2和A2A2基因型。根据血型A的分布没有显着关联，B,观察AMI患者和健康个体的O和AB。调整年龄后，BB基因型受试者的AMI几率是OO基因型受试者的3.32倍，性别,身体质量指数,心率,总胆固醇,和腰围[AOR（95%CI）=3.32（1.36-8.08），p值=0.008]。
UASSIGNED：我们以医院为基础的研究表明ABO基因型BB与AMI的风险显著相关。BB基因型的这种有害作用可能与巴基斯坦人群中AMI的发展有关。
未经评估：在一项比较的横断面研究中，相同数量的成人AMI患者和健康对照（每组n=275；年龄范围30-70岁，男性和女性）都是从阿加汗大学和NICVD招募的，卡拉奇,知情同意。分析血液样品的ABO血型和其他生物标志物。采用PCR和RFLP技术确定ABO基因型。多项回归用于评估基因型与AMI风险的关联。
UNASSIGNED：观察到13种不同的ABO基因型组合，而未检测到O2O2和A2A2基因型。根据血型A的分布没有显着关联，B,观察AMI患者和健康个体的O和AB。调整年龄后，BB基因型受试者的AMI几率是OO基因型受试者的3.32倍，性别,身体质量指数,心率,总胆固醇,和腰围[AOR（95%CI）=3.32（1.36-8.08），p值=0.008]。
UASSIGNED：我们以医院为基础的研究表明ABO基因型BB与AMI的风险显著相关。BB基因型的这种有害作用可能与巴基斯坦人群中AMI的发展有关。
