Abstract：
UNASSIGNED: This retrospective study aimed to determine the incidence, risk factors, and outcomes of acute kidney injury (AKI) in neonates following the arterial switch operation (ASO) for transposition of great arteries (TGA).
UNASSIGNED: Retrospective review of medical data of children who underwent ASO in 2019-2020 in the Ukrainian Children\'s Cardiac Center.
UNASSIGNED: 76 consecutive neonatal patients were included, 48 developed AKI after ASO (51.7%), and 24 - had severe AKI (25.8%). Severe AKI development was associated with longer cross-clamp time: 82 (61-127) versus 73.5 (53-136) in the non-severe AKI group (p = 0.02). 76 min of cross-clamp time were defined as a threshold value for increased severe AKI risk, OR 4.4 (95% CI: 1.5 - 13, p = 0.01). Higher lactate levels during cardiopulmonary bypass (CPB) increased severe AKI development risk, OR 1.5 (95% CI: 1.0 - 2.0, p = 0.03). Children with severe AKI had prolonged mechanical ventilation, longer time to negative fluid balance, and higher postoperative day 3 (POD3) Inotropic Score (IS). Only one patient required peritoneal dialysis.
UNASSIGNED: In our study, 51.7% of patients developed AKI after ASO, 25.8%-severe AKI. Prolonged cross-clamp time and higher lactate levels during cardiopulmonary bypass increased the risk for severe AKI development. The development of AKI was associated with prolonged mechanical ventilation, longer time to negative fluid balance, higher POD 3 Inotropic Score.
UNASSIGNED: Retrospective review of medical data of children who underwent ASO in 2019-2020 in the Ukrainian Children\'s Cardiac Center.
UNASSIGNED: 76 consecutive neonatal patients were included, 48 developed AKI after ASO (51.7%), and 24 - had severe AKI (25.8%). Severe AKI development was associated with longer cross-clamp time: 82 (61-127) versus 73.5 (53-136) in the non-severe AKI group (p = 0.02). 76 min of cross-clamp time were defined as a threshold value for increased severe AKI risk, OR 4.4 (95% CI: 1.5 - 13, p = 0.01). Higher lactate levels during cardiopulmonary bypass (CPB) increased severe AKI development risk, OR 1.5 (95% CI: 1.0 - 2.0, p = 0.03). Children with severe AKI had prolonged mechanical ventilation, longer time to negative fluid balance, and higher postoperative day 3 (POD3) Inotropic Score (IS). Only one patient required peritoneal dialysis.
UNASSIGNED: In our study, 51.7% of patients developed AKI after ASO, 25.8%-severe AKI. Prolonged cross-clamp time and higher lactate levels during cardiopulmonary bypass increased the risk for severe AKI development. The development of AKI was associated with prolonged mechanical ventilation, longer time to negative fluid balance, higher POD 3 Inotropic Score.
摘要：
未经评估：这项回顾性研究旨在确定发病率，危险因素，大动脉转位（TGA）动脉转换手术（ASO）后新生儿急性肾损伤（AKI）的结局。
UNASSIGNED：对2019-2020年在乌克兰儿童心脏中心接受ASO的儿童的医学数据进行回顾性审查。
UNASSIGNED：包括76名连续的新生儿患者，48例ASO后发生AKI（51.7%），和24-有严重的AKI（25.8％）。严重AKI发展与更长的交叉钳夹时间相关：非严重AKI组82（61-127）对73.5（53-136）（p=0.02）。76分钟的交叉钳制时间被定义为严重AKI风险增加的阈值。OR4.4（95%CI：1.5-13，p=0.01）。体外循环（CPB）期间较高的乳酸水平会增加严重的AKI发展风险，OR1.5（95%CI：1.0-2.0，p=0.03）。患有严重AKI的儿童有长时间的机械通气，达到液体负平衡的时间更长，术后第3天（POD3）肌力评分（IS）较高。只有一名患者需要腹膜透析。
未经批准：在我们的研究中，51.7%的患者在ASO后发生AKI,25.8%-重度AKI。体外循环期间延长的交叉钳夹时间和较高的乳酸水平增加了严重AKI发展的风险。AKI的发展与长时间的机械通气有关，达到液体负平衡的时间更长，POD3变力评分较高。
UNASSIGNED：对2019-2020年在乌克兰儿童心脏中心接受ASO的儿童的医学数据进行回顾性审查。
UNASSIGNED：包括76名连续的新生儿患者，48例ASO后发生AKI（51.7%），和24-有严重的AKI（25.8％）。严重AKI发展与更长的交叉钳夹时间相关：非严重AKI组82（61-127）对73.5（53-136）（p=0.02）。76分钟的交叉钳制时间被定义为严重AKI风险增加的阈值。OR4.4（95%CI：1.5-13，p=0.01）。体外循环（CPB）期间较高的乳酸水平会增加严重的AKI发展风险，OR1.5（95%CI：1.0-2.0，p=0.03）。患有严重AKI的儿童有长时间的机械通气，达到液体负平衡的时间更长，术后第3天（POD3）肌力评分（IS）较高。只有一名患者需要腹膜透析。
未经批准：在我们的研究中，51.7%的患者在ASO后发生AKI,25.8%-重度AKI。体外循环期间延长的交叉钳夹时间和较高的乳酸水平增加了严重AKI发展的风险。AKI的发展与长时间的机械通气有关，达到液体负平衡的时间更长，POD3变力评分较高。
