UNASSIGNED: 94 healthy individuals participated in a longitudinal study with 30-day follow-up. NGF was injected into the right masseter muscle on Day 0 and Day 2. Participants attended laboratory sessions to assess pain (Numerical Rating Scale; NRS), functional limitation (mouth opening distance, Jaw Functional Limitation Scale; JFLS) and mechanical sensitization (pressure pain thresholds; PPTs) on Days 0, 2 and 5 and completed twice daily electronic pain dairies from Day 0 to day 30.
UNASSIGNED: Peak pain averaged 2.0/10 (95 % CI: 1.6-2.4) at rest and 4.3/10 (95 % CI: 3.9-4.8) on chewing. Pain-free mouth opening distance reduced from 5.0 cm (95 % CI: 4.8-5.1 cm) on Day 0 to 3.7 cm (95 % CI: 3.5-3.9 cm) on Day 5. The greatest reduction in PPTs was observed over the masseter muscle. Females experienced higher pain, greater functional impairment, and greater sensitivity to mechanical stimuli than males.
UNASSIGNED: Intramuscular injection of NGF is a useful model with which to explore the mechanisms, and sex differences, present in clinical TMD.
UNASSIGNED:94名健康个体参与了一项30天随访的纵向研究。在第0天和第2天,将NGF注射到右咬肌。参与者参加了评估疼痛的实验室会议(数字评定量表;NRS),功能限制(开口距离,第0、2和5天的颌骨功能限制量表;JFLS)和机械致敏(压力疼痛阈值;PPTs),并从第0天到第30天每天两次完成电子疼痛护理。
非ASSIGNED:休息时疼痛峰值平均为2.0/10(95%CI:1.6-2.4),咀嚼时平均为4.3/10(95%CI:3.9-4.8)。无痛张口距离从第0天的5.0cm(95%CI:4.8-5.1cm)减少到第5天的3.7cm(95%CI:3.5-3.9cm)。在咬肌上观察到PPTs的最大减少。女性经历了更高的疼痛,更大的功能损害,对机械刺激的敏感度高于男性。
UNASSIGNED:肌内注射NGF是探索机制的有用模型,和性别差异,目前在临床TMD。