UNASSIGNED: We retrospectively analyzed the seizure outcomes of VNS with at least 1 year of follow-up in all patients with pharmacoresistant epilepsy secondary to encephalomalacia. Based on the effectiveness of VNS (≥50% or <50% reduction in seizure frequency), patients were divided into two subgroups: responders and non-responders. Preoperative data were analyzed to screen for potential predictors of VNS effectiveness.
UNASSIGNED: A total of 93 patients with epilepsy secondary to encephalomalacia who underwent VNS therapy were recruited. Responders were found in 64.5% of patients, and 16.1% of patients achieved seizure freedom at the last follow-up. In addition, the responder rate increased over time, with 36.6, 50.5, 64.5, and 65.4% at the 3-, 6-, 12-, and 24-month follow-ups, respectively. After multivariate analysis, seizure onset in adults (>18 years old) (OR: 0.236, 95%CI: 0.059-0.949) was found to be a positive predictor, and the bilateral interictal epileptic discharges (IEDs) (OR: 3.397, 95%CI: 1.148-10.054) and the bilateral encephalomalacia on MRI (OR: 3.193, 95%CI: 1.217-8.381) were found to be negative predictors of VNS effectiveness.
UNASSIGNED: The results demonstrated the effectiveness and safety of VNS therapy in patients with pharmacoresistant epilepsy secondary to encephalomalacia. Patients with seizure onset in adults (>18 years old), unilateral IEDs, or unilateral encephalomalacia on MRI were found to have better seizure outcomes after VNS therapy.
UNASSIGNED:我们回顾性分析了VNS的癫痫发作结果,并对所有继发于脑软化症的药物抗性癫痫患者进行了至少1年的随访。基于VNS的有效性(发作频率降低≥50%或<50%),患者分为两个亚组:应答者和非应答者.分析术前数据以筛选VNS有效性的潜在预测因子。
UNASSIGNED:共纳入93例接受VNS治疗的脑软化继发癫痫患者。在64.5%的患者中发现了响应者,16.1%的患者在最后一次随访时实现了癫痫发作自由。此外,响应率随着时间的推移而增加,在3-,分别为36.6、50.5、64.5和65.4%,6-,12-,24个月的随访,分别。经过多变量分析,成人癫痫发作(>18岁)(OR:0.236,95CI:0.059-0.949)被发现是一个积极的预测因子,双侧发作间癫痫放电(IEDs)(OR:3.397,95CI:1.148-10.054)和MRI上的双侧脑软化(OR:3.193,95CI:1.217-8.381)被发现是VNS有效性的阴性预测因子。
UNASSIGNED:结果证明了VNS治疗对继发于脑软化的药物耐药性癫痫患者的有效性和安全性。成人癫痫发作患者(>18岁),单边IED,或在MRI上发现单侧脑软化在VNS治疗后有更好的癫痫发作结局.