PDF(Pubmed)
Abstract：
Interdigital hyperplasia (IH) is a fold of fibrous tissue protruding into the interdigital space that rarely occurs in sheep. Interdigital hyperplasia secondary infected with bovine digital dermatitis (BDD) treponemes has been reported in cattle in the course of the increasing spread of classical BDD lesions. In this report, we describe proliferative/ulcerative interdigital lesions associated with contagious ovine digital dermatitis (CODD) treponemes and clinically scored as (IH+CODD), occurring in both hind limbs of a ram and the left hindlimb of a ewe. Both cases exhibited epidermal hyperplasia, parakeratosis and focal-extensive areas of epidermal necrosis with numerous infiltrating neutrophils. Treponema PCR and fluorescence in situ hybridization (FISH) were positive for Treponema phylotype 1 (PT1). In addition, Dichelobacter (D.) nodosus and Porphyromonas (P.) levii were detected in the biopsy by PCR. In three slaughter sheep, without claw lesions, which were kept together with both affected sheep, Treponema spp. were detected neither with PCR nor FISH; the PCRs for D. nodosus and P. levii were also negative. Complete clinical healing occurred in the ewe within 6 weeks after three local applications of a chlortetracycline spray in 2 weeks intervals. This report is the first description of IH+CODD in sheep as demonstrated by a combination of histopathological and molecular analyses.
摘要：
指间增生（IH）是纤维组织突出到指间空间的褶皱，在绵羊中很少发生。据报导，二次沾染牛指性皮炎(BDD)螺旋体在牛经典BDD病变进程中的散布日趋增多。在这份报告中,我们描述了与传染性羊指皮炎（CODD）螺旋体相关的增生性/溃疡性指间病变，临床评分为（IHCODD），发生在公羊的后肢和母羊的左后肢。两例均表现为表皮增生,角化不全和表皮坏死的局灶性广泛区域，有许多浸润的中性粒细胞。螺旋体PCR和荧光原位杂交（FISH）对螺旋体表型1（PT1）呈阳性。此外,二重杆菌属(D.)结节和卟啉虫(P.)通过PCR在活检中检测到了亚氮。在三只屠宰的绵羊中，没有爪病变，与两只受影响的绵羊一起饲养，密螺旋体属。用PCR和FISH均未检测到；结节性念珠菌和负重念珠菌的PCR也为阴性。每隔2周局部应用3次金霉素喷雾剂后，母羊在6周内发生了完全的临床愈合。该报告是通过组织病理学和分子分析相结合证明的绵羊中IHCODD的首次描述。
