PDF(Pubmed)
Abstract：
Mucosal melanomas (MM) are a rare type of melanomas commonly found in the vulvovaginal, anorectal, and respiratory tract. In this case report, a 71-year-old female presented to her OB/GYN clinic with dark raised mass on her right labial region adjacent to the perineum. Past medical and surgical history of note included third-degree uterine prolapse, senile vaginitis, fibrocystic changes of the breasts bilaterally, hypothyroidism, hypertension, as well as a past hysterectomy and anterior colporrhaphy. Upon further workup, the 2.7 x 1.8 x 2 cm polyploid mass was biopsied and was found to be consistent with malignant melanoma. The patient then underwent a wide local excision confirming that the lesion was a nodular vulvar melanoma with superficial ulcerations and lymphovascular invasion of the vulvar region. Post-wide local incisions were found to be healed well after the procedure and the patient was referred to a gynecological oncologist for continuous monitoring. The purpose of this case report is to bring awareness of melanomas arising in atypical regions. While MMs are rare in comparison to cutaneous melanomas (CM), the prognosis can be poor if not caught early.
摘要：
粘膜黑素瘤（MM）是一种罕见的黑色素瘤，常见于外阴阴道，肛门直肠,和呼吸道。在这个案例报告中,一名71岁的女性出现在她的OB/GYN诊所，在她的会阴附近的右唇区有黑色凸起的肿块。既往病史和手术史包括三度子宫脱垂，老年性阴道炎,双侧乳房的纤维囊性改变，甲状腺功能减退,高血压,以及过去的子宫切除术和前阴道修补术。在进一步的工作中，对2.7×1.8×2cm多倍体肿块进行活检,发现与恶性黑色素瘤一致.然后，患者接受了广泛的局部切除术，确认病变是结节性外阴黑色素瘤，伴有浅表溃疡和外阴区域的淋巴血管浸润。手术后发现局部切口愈合良好，患者被转诊至妇科肿瘤科医生进行连续监测。本病例报告的目的是提高对非典型区域黑素瘤的认识。虽然与皮肤黑色素瘤（CM）相比，MM很少见，如果不及早发现，预后可能较差。
