PDF(Pubmed)
Abstract：
UNASSIGNED: Right ventricle (RV) mass is an imaging biomarker of mean pulmonary artery pressure (MPAP) and pulmonary vascular resistance (PVR). Some methods of RV mass measurement on cardiac MRI (CMR) exclude RV trabeculation. This study assessed the reproducibility of measurement methods and evaluated whether the inclusion of trabeculation in RV mass affects diagnostic accuracy in suspected pulmonary hypertension (PH).
UNASSIGNED: Two populations were enrolled prospectively. (i) A total of 144 patients with suspected PH who underwent CMR followed by right heart catheterization (RHC). Total RV mass (including trabeculation) and compacted RV mass (excluding trabeculation) were measured on the end-diastolic CMR images using both semi-automated pixel-intensity-based thresholding and manual contouring techniques. (ii) A total of 15 healthy volunteers and 15 patients with known PH. Interobserver agreement and scan-scan reproducibility were evaluated for RV mass measurements using the semi-automated thresholding and manual contouring techniques.
UNASSIGNED: Total RV mass correlated more strongly with MPAP and PVR (r = 0.59 and 0.63) than compacted RV mass (r = 0.25 and 0.38). Using a diagnostic threshold of MPAP ≥ 25 mmHg, ROC analysis showed better performance for total RV mass (AUC 0.77 and 0.81) compared to compacted RV mass (AUC 0.61 and 0.66) when both parameters were indexed for LV mass. Semi-automated thresholding was twice as fast as manual contouring (p < 0.001).
UNASSIGNED: Using a semi-automated thresholding technique, inclusion of trabecular mass and indexing RV mass for LV mass (ventricular mass index), improves the diagnostic accuracy of CMR measurements in suspected PH.
UNASSIGNED: Two populations were enrolled prospectively. (i) A total of 144 patients with suspected PH who underwent CMR followed by right heart catheterization (RHC). Total RV mass (including trabeculation) and compacted RV mass (excluding trabeculation) were measured on the end-diastolic CMR images using both semi-automated pixel-intensity-based thresholding and manual contouring techniques. (ii) A total of 15 healthy volunteers and 15 patients with known PH. Interobserver agreement and scan-scan reproducibility were evaluated for RV mass measurements using the semi-automated thresholding and manual contouring techniques.
UNASSIGNED: Total RV mass correlated more strongly with MPAP and PVR (r = 0.59 and 0.63) than compacted RV mass (r = 0.25 and 0.38). Using a diagnostic threshold of MPAP ≥ 25 mmHg, ROC analysis showed better performance for total RV mass (AUC 0.77 and 0.81) compared to compacted RV mass (AUC 0.61 and 0.66) when both parameters were indexed for LV mass. Semi-automated thresholding was twice as fast as manual contouring (p < 0.001).
UNASSIGNED: Using a semi-automated thresholding technique, inclusion of trabecular mass and indexing RV mass for LV mass (ventricular mass index), improves the diagnostic accuracy of CMR measurements in suspected PH.
摘要：
未经证实：右心室（RV）肿块是平均肺动脉压（MPAP）和肺血管阻力（PVR）的影像学生物标志物。在心脏MRI（CMR）上测量RV质量的一些方法排除了RV小梁。这项研究评估了测量方法的可重复性，并评估了RV肿块中包含小梁是否会影响可疑肺动脉高压（PH）的诊断准确性。
UNASSIGNED：有两个群体被前瞻性地纳入。（i）总共144例疑似PH患者接受了CMR，然后进行了右心导管插入术（RHC）。使用基于半自动像素强度的阈值和手动轮廓技术，在舒张末期CMR图像上测量了RV总质量（包括小梁）和压缩的RV质量（不包括小梁）。(ii)总共15名健康志愿者和15名已知PH的患者。使用半自动阈值和手动轮廓技术评估了观察者之间的一致性和扫描扫描可重复性，以进行RV质量测量。
未经证实：总RV质量与MPAP和PVR（r=0.59和0.63）的相关性比压实RV质量（r=0.25和0.38）更强。使用MPAP≥25mmHg的诊断阈值，当两个参数都针对LV质量索引时,ROC分析显示总RV质量(AUC0.77和0.81)与压实RV质量(AUC0.61和0.66)相比更好的性能。半自动阈值的速度是手动轮廓绘制的两倍（p<0.001）。
UNASSIGNED：使用半自动阈值化技术，包括小梁质量和左心室质量的分度RV质量（心室质量指数），提高了可疑PH中CMR测量的诊断准确性。
UNASSIGNED：有两个群体被前瞻性地纳入。（i）总共144例疑似PH患者接受了CMR，然后进行了右心导管插入术（RHC）。使用基于半自动像素强度的阈值和手动轮廓技术，在舒张末期CMR图像上测量了RV总质量（包括小梁）和压缩的RV质量（不包括小梁）。(ii)总共15名健康志愿者和15名已知PH的患者。使用半自动阈值和手动轮廓技术评估了观察者之间的一致性和扫描扫描可重复性，以进行RV质量测量。
未经证实：总RV质量与MPAP和PVR（r=0.59和0.63）的相关性比压实RV质量（r=0.25和0.38）更强。使用MPAP≥25mmHg的诊断阈值，当两个参数都针对LV质量索引时,ROC分析显示总RV质量(AUC0.77和0.81)与压实RV质量(AUC0.61和0.66)相比更好的性能。半自动阈值的速度是手动轮廓绘制的两倍（p<0.001）。
UNASSIGNED：使用半自动阈值化技术，包括小梁质量和左心室质量的分度RV质量（心室质量指数），提高了可疑PH中CMR测量的诊断准确性。
