Abstract：
Epilepsy is a common neurological disorder associated with alterations of excitation-inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the most prevalent form of inhibitory neurotransmission and is strongly implicated in both the pathophysiology and treatment of epilepsy, serving as a primary target for antiseizure medications for over a century. It is now established that GABA exerts a multifaceted influence through an array of GABAA receptor subtypes that extends far beyond simply negating excitatory activity. As the role of GABAA neurotransmission within inhibitory circuits is elaborated, this will enable the development of precision therapies that correct the network dysfunction underlying epileptic pathology.
摘要：
癫痫是一种常见的神经系统疾病，与脑神经元网络中的兴奋-抑制平衡改变有关。GABAA受体神经传递是最普遍的抑制性神经传递形式，与癫痫的病理生理学和治疗密切相关。一个多世纪以来一直是抗癫痫药物的主要目标。现在已经确定，GABA通过一系列GABAA受体亚型发挥多方面的影响，这些亚型远远超出了简单地否定兴奋活性。由于阐述了GABAA神经传递在抑制回路中的作用，这将有助于开发精确疗法，以纠正癫痫病理背后的网络功能障碍。
