Abstract：
This study investigated outcomes of children born to women who seroconverted to rubella immune during pregnancy. In a prior 2012-2013 study of 296 women who were rubella nonimmune, 26 (8.8%) seroconverted to rubella immune during pregnancy. These same women and their now 8-9 years-old children were queried as to the children\'s developmental health. After removing exclusions and those lost to follow-up, the total response rate was 115/204 (56.4%). Three sets of twins in the nonimmune group increased the total to 118. The seroconversion group had more autism (12.5% vs. 3.9%, p = 0.19), ADHD (37.5% vs. 18.6%, p = 0.10), and any developmental disability (43.8% vs. 31.4%, p = 0.39) but none showed a statistical difference between the two groups. Compared to Autism and Developmental Disabilities Monitoring data, the seroconversion group had a greater prevalence of autism (odds ratio [OR] 6.07, p = 0.051, nonsignificant); and to data derived from the National Health Interview Survey, a nonsignificant higher odds of autism (OR 5.57, p = 0.060), higher odds of ADHD (OR 5.65, p = 0.0027) and of any developmental disability (OR 3.59, p = 0.014). The nonimmune group also demonstrated a statistically significant increase for both ADHD and any developmental disability, but not for autism.
摘要：
这项研究调查了在怀孕期间血清转化为风疹免疫的妇女所生的孩子的结局。在2012-2013年之前的一项研究中，296名风疹非免疫女性，26（8.8％）在怀孕期间血清转化为风疹免疫。这些妇女和她们现在的8-9岁的孩子被问及孩子的发育健康。在删除排除和丢失到后续行动后，总有效率为115/204(56.4%).非免疫组中的三对双胞胎总数增加到118。血清转换组有更多的自闭症(12.5%对3.9%，P=.19)，ADHD（37.5％对18.6％，P=.10)，和任何发育障碍(43.8%对31.4%，P=.39），但两组之间均无统计学差异。与自闭症和发育障碍监测数据相比，血清转换组的自闭症患病率更高（OR6.07，P=0.051，无统计学意义）；从国家健康访谈调查得出的数据，孤独症的几率非显着较高（OR5.57，P=0.060），ADHD(OR5.65,P=0.0027)和任何发育障碍(OR3.59,P=0.014)的几率更高。非免疫组也显示出ADHD和任何发育障碍的统计学显着增加，但不是自闭症。本文受版权保护。保留所有权利。
