Abstract：
Cutaneous manifestations in coronavirus disease 2019 (COVID-19) patients may possess prognostic value for identifying potentially severe cases. This systematic review investigated whether dermatological features are associated with COVID-19 outcomes in elderly patients. Literature retrieval was conducted on May 11, 2022, from databases, hand-searching, and tracing citations. Following selection against eligibility criteria, the remaining records were evaluated utilizing the National Heart, Lung, and Blood Institute Study Quality Assessment Tool or Newcastle-Ottawa Scale. The pooled individual data were subsequently analyzed using the Cochran-Mantel-Haenszel test to calculate the odds ratio (ORs) and confidence intervals (CIs) for the severity and mortality of each skin lesion type. We incorporated 70 articles, including 180 and 117 entries, with information regarding disease severity and mortality. Further analysis revealed that vascular type was the skin lesion most frequently noticed in confirmed COVID-19 elderly patients (46.2%) and was associated with an increased risk of developing advanced disease (OR 7.32, 95% CI 3.39-15.81) and the ensuing termination (OR 5.73, 95% CI 2.46-13.36). The converse phenomenon was observed in maculopapular type (severity OR 0.27, 95% CI 0.14-0.52; mortality OR 0.10, 95% CI 0.03-0.36). In conclusion, skin manifestations may predict COVID-19 severity and mortality in the senior group.
摘要：
2019年冠状病毒病（COVID-19）患者的皮肤表现可能对识别潜在的严重病例具有预后价值。这项系统评价调查了老年患者的皮肤病学特征是否与COVID-19结局相关。文献检索于2022年5月11日从数据库中进行，手工搜索,并追踪引文。根据资格标准进行选择后，剩余的记录使用国家心脏进行评估，肺，和血液研究所研究质量评估工具或纽卡斯尔-渥太华量表。随后使用Cochran-Mantel-Haenszel检验分析合并的个体数据,以计算每种皮肤病变类型的严重程度和死亡率的比值比(OR)和置信区间(CI)。我们纳入了70篇文章，包括180和117个条目，关于疾病严重程度和死亡率的信息。进一步分析显示，血管类型是确诊的COVID-19老年患者中最常见的皮肤病变(46.2%)，并与发展为晚期疾病的风险增加(OR7.32，95%CI3.39-15.81)和随后终止疾病的风险增加(OR5.73，95%CI2.46-13.36)相关。在斑丘疹型中观察到相反的现象（严重程度OR0.27，95％CI0.14-0.52；死亡率OR0.10，95％CI0.03-0.36）。总之,皮肤表现可预测老年组COVID-19的严重程度和死亡率.
