Abstract：
OBJECTIVE: This study aimed to summarize and analyze the clinical data of intestinal tuberculosis (ITB) in order to provide guidance for accurate diagnosis and treatment of ITB.
METHODS: This study consecutively included patients with ITB who were admitted to our hospital from 2008 to 2021 and retrospectively analyzed their clinical features.
RESULTS: Forty-six patients were included. The most common clinical symptom was weight loss (67.4%). Seventy percent of 20 patients were positive for tuberculin skin test; 57.1% of 14 patients were positive for mycobacterium tuberculosis specific cellular immune response test, while 84.6% of 26 patients were positive for tuberculosis infection T cell spot test. By chest computed tomography (CT) examination, 25% and 5.6% of 36 patients were diagnosed with active pulmonary tuberculosis and with inactive pulmonary tuberculosis, respectively. By abdominal CT examination, the most common sign was abdominal lymph node enlargement (43.2%). Forty-two patients underwent colonoscopy, and the most common endoscopic manifestation was ileocecal ulcer (59.5%), followed by colonic ulcer (35.7%) and ileocecal valve deformity (26.2%). ITB most frequently involved the terminal ileum/ileocecal region (76.1%). Granulomatous inflammation with multinucleated giant cells and caseous necrosis was found via endoscopic biopsies, the ultrasound-guided percutaneous biopsy of enlarged mesentery lymph nodes, and surgical interventions. The acid-fast bacilli were discovered in 53.1% of 32 samples. Twenty-one cases highly suspected of ITB were confirmed after responding to empiric anti-tuberculosis therapy.
CONCLUSIONS: It was necessary to comprehensively analyze clinical features to make an accurate diagnosis of ITB and aid in distinguishing ITB from diseases such as Crohn\'s disease and malignant tumors.
METHODS: This study consecutively included patients with ITB who were admitted to our hospital from 2008 to 2021 and retrospectively analyzed their clinical features.
RESULTS: Forty-six patients were included. The most common clinical symptom was weight loss (67.4%). Seventy percent of 20 patients were positive for tuberculin skin test; 57.1% of 14 patients were positive for mycobacterium tuberculosis specific cellular immune response test, while 84.6% of 26 patients were positive for tuberculosis infection T cell spot test. By chest computed tomography (CT) examination, 25% and 5.6% of 36 patients were diagnosed with active pulmonary tuberculosis and with inactive pulmonary tuberculosis, respectively. By abdominal CT examination, the most common sign was abdominal lymph node enlargement (43.2%). Forty-two patients underwent colonoscopy, and the most common endoscopic manifestation was ileocecal ulcer (59.5%), followed by colonic ulcer (35.7%) and ileocecal valve deformity (26.2%). ITB most frequently involved the terminal ileum/ileocecal region (76.1%). Granulomatous inflammation with multinucleated giant cells and caseous necrosis was found via endoscopic biopsies, the ultrasound-guided percutaneous biopsy of enlarged mesentery lymph nodes, and surgical interventions. The acid-fast bacilli were discovered in 53.1% of 32 samples. Twenty-one cases highly suspected of ITB were confirmed after responding to empiric anti-tuberculosis therapy.
CONCLUSIONS: It was necessary to comprehensively analyze clinical features to make an accurate diagnosis of ITB and aid in distinguishing ITB from diseases such as Crohn\'s disease and malignant tumors.
摘要：
目的：本研究旨在总结和分析肠结核（ITB）的临床资料，为ITB的准确诊断和治疗提供指导。
方法：本研究连续纳入我院2008-2021年收治的ITB患者，对其临床特征进行回顾性分析。
结果：纳入46例患者。最常见的临床症状是体重减轻（67.4%）。20例患者中70%的结核菌素皮试阳性;14例患者中57.1%的结核杆菌特异性细胞免疫应答试验阳性,26例患者中结核感染T细胞斑点试验阳性的占84.6%。通过胸部计算机断层扫描（CT）检查，36例患者中诊断为活动性肺结核和活动性肺结核分别占25%和5.6%,分别。通过腹部CT检查,最常见的体征是腹部淋巴结肿大（43.2％）。42例患者接受了结肠镜检查，最常见的内镜表现是回盲部溃疡（59.5%），其次是结肠溃疡（35.7％）和回盲瓣畸形（26.2％）。ITB最常见的是回肠末端/回盲区（76.1％）。通过内窥镜活检发现肉芽肿性炎症与多核巨细胞和干酪样坏死，超声引导下经皮穿刺活检肠系膜淋巴结肿大，和手术干预。在32份样品中，有53.1%发现了抗酸杆菌。对经验性抗结核治疗有反应后，确认了21例高度怀疑ITB的病例。
结论：有必要综合分析临床特征，以准确诊断ITB，并有助于将ITB与克罗恩病和恶性肿瘤等疾病区分开来。
方法：本研究连续纳入我院2008-2021年收治的ITB患者，对其临床特征进行回顾性分析。
结果：纳入46例患者。最常见的临床症状是体重减轻（67.4%）。20例患者中70%的结核菌素皮试阳性;14例患者中57.1%的结核杆菌特异性细胞免疫应答试验阳性,26例患者中结核感染T细胞斑点试验阳性的占84.6%。通过胸部计算机断层扫描（CT）检查，36例患者中诊断为活动性肺结核和活动性肺结核分别占25%和5.6%,分别。通过腹部CT检查,最常见的体征是腹部淋巴结肿大（43.2％）。42例患者接受了结肠镜检查，最常见的内镜表现是回盲部溃疡（59.5%），其次是结肠溃疡（35.7％）和回盲瓣畸形（26.2％）。ITB最常见的是回肠末端/回盲区（76.1％）。通过内窥镜活检发现肉芽肿性炎症与多核巨细胞和干酪样坏死，超声引导下经皮穿刺活检肠系膜淋巴结肿大，和手术干预。在32份样品中，有53.1%发现了抗酸杆菌。对经验性抗结核治疗有反应后，确认了21例高度怀疑ITB的病例。
结论：有必要综合分析临床特征，以准确诊断ITB，并有助于将ITB与克罗恩病和恶性肿瘤等疾病区分开来。
