Abstract:
Background and Aim: Spontaneous bacterial peritonitis (SBP) is a common infection in liver cirrhosis. This systematic review and meta-analysis provide detailed information on the prevalence of SBP among hepatitis B virus (HBV) and hepatitis C virus (HCV)-related liver cirrhosis globally. Methods: A systematic search for articles describing the prevalence of SBP in HBV and HCV-related cirrhosis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Our search returned ten (10) eligible articles involving 1713 viral cirrhosis cases representing eight (8) countries. A meta-analysis was performed on our eligible studies using the random effect model. A protocol was registered with PROSPERO (CRD42022321790). Results: The pooled prevalence of SBP in HBV-associated cirrhosis had the highest estimate [8.0% (95% CI, 2.7−21.0%; I2 = 96.13%; p < 0.001)], followed by SBP in HCV-associated liver cirrhosis [4.0% (95% CI, 1.3%−11.5%; I2 = 88.99%; p < 0.001)]. China (61.8%, CI: 57.1−66.3%), the USA (50.0%, CI: 34.6−65.4%), and Holland (31.1%, CI: 21.6−42.5%) had the highest estimate for SBP in HBV associated liver cirrhosis, SBP in HCV associated liver cirrhosis and SBP in HBV + HCV associated liver cirrhosis respectively. There was a significant difference in the prevalence of SBP in viral hepatitis-associated liver cirrhosis with the year of sampling and method of SBP detection at P < 0.001. There was an increase in SBP incidence at the beginning of 2016 across the liver cirrhosis in this study. Conclusion: The findings of this review revealed a rise in the incidence of SBP in viral hepatitis over the last decade. The latter indicates a possible future rise in the global prevalence of SBP among HBV and HCV-related liver cirrhosis.
摘要:
目的:自发性细菌性腹膜炎(SBP)是肝硬化的常见感染。这项系统评价和荟萃分析提供了全球乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)相关肝硬化中SBP患病率的详细信息。
方法:根据系统评价和荟萃分析(PRISMA)指南的首选报告项目,对描述HBV和HCV相关肝硬化中SBP患病率的文章进行了系统搜索。我们的搜索返回了十(10)篇合格文章,涉及代表八(8)个国家的1713例病毒性肝硬化病例。使用随机效应模型对我们符合条件的研究进行了荟萃分析。协议已在PROSPERO(CRD42022321790)注册。
结果:HBV相关肝硬化中SBP的汇总患病率估计最高[8.0%(95%CI,2.7-21.0%;I2=96.13%;p<<0.001)],其次是HCV相关肝硬化的SBP[4.0%(95%CI,1.3%-11.5%;I2=88.99%;p<0.001)]。中国(61.8%,CI:57.1-66.3%),美国(50.0%,CI:34.6-65.4%),和荷兰(31.1%,CI:21.6-42.5%)对HBV相关肝硬化的SBP估计最高,HCV相关性肝硬化中的SBP和HBV+HCV相关性肝硬化中的SBP。病毒性肝炎相关肝硬化中SBP的患病率与采样年份和SBP检测方法在P&lt;0.001有显着性差异。在这项研究中,2016年初肝硬化的SBP发病率增加。
结论:这篇综述的结果显示,在过去十年中,病毒性肝炎中SBP的发病率有所上升。后者表明HBV和HCV相关肝硬化中SBP的全球患病率可能在未来上升。