关键词: charge syndrome choanal atresia craniofacial abnormalities infant nasopharynx

来  源:   DOI:10.3390/children10010091

Abstract:
Choanal atresia is the most common congenital anatomical abnormality of the nasal cavities, manifested with a clinical picture of neonatal respiratory distress. The treatment requires interdisciplinary management based mainly on tertiary referral centre experiences. However, there is a lack of high-quality evidence in the available literature. Recommendations were prepared based on a systematic review of the supporting literature: on a website survey addressed to the participating authors consisting of 28 questions and on five live meetings. The initial response to the recommendations was determined at their presentation at the sectional meeting of the section for otorhinolaryngology of the Slovenian Medical Association. Then, reactions from the professional public were accepted until the recommendations were presented at the Expert Council for Otorhinolaryngology of the Slovenian Medical Association. A systematic literature review identified eight systematic reviews or meta-analyses and four randomized controlled clinical trials. Thirty-four recommendations for diagnosis, treatment and postoperative management were consolidated. The paper presents the proposal and first Slovenian recommendations for treating patients with choanal atresia. They are based on foreign medical institutions\' published literature and our clinical experience. They represent the basic requirements of diagnostics and may represent an essential guide in treatment.
摘要:
鼻孔闭锁是最常见的先天性鼻腔解剖异常,表现为新生儿呼吸窘迫的临床表现。治疗需要跨学科管理,主要基于三级转诊中心的经验。然而,现有文献中缺乏高质量的证据。建议是根据对支持文献的系统审查编写的:针对参与作者的网站调查,包括28个问题和5次现场会议。对这些建议的最初反应是在斯洛文尼亚医学协会耳鼻咽喉科的部分会议上进行的介绍中确定的。然后,在斯洛文尼亚医学会耳鼻咽喉科专家委员会提出建议之前,专业公众的反应被接受.系统文献综述确定了8项系统评价或荟萃分析和4项随机对照临床试验。三十四项诊断建议,治疗和术后管理得到巩固。本文提出了治疗后鼻孔闭锁患者的建议和斯洛文尼亚的第一个建议。它们基于国外医疗机构发表的文献和我们的临床经验。它们代表诊断的基本要求,可能代表治疗的基本指南。
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