Abstract：
(1) Background: The emergence of multidrug resistance enterococci is a major public health concern. This study aimed to determine the prevalence and antimicrobial resistance of enterococci isolated from blood cultures over a five-year period (2016−2020) at public hospitals in South Africa. (2): Methods: A retrospective analysis of clinical enterococci isolated from bloodstream infection samples at the South African public hospitals was conducted. The ESKAPE dataset from January 2016 to December 2020 was obtained from the central data warehouse (CDW) at the National Health Laboratory Service (NHLS). (3): Results: Following de-duplication, a total of 130,352/306,592 organisms isolated from blood cultures were identified as ESKAPE pathogens. In this study, K. pneumoniae (25%; 33,082/130,352), was the most frequently isolated pathogen from blood cultures, followed by S. aureus (23%; 29,922/130,352) and enterococci (16%; 21,339/130,352). Of the enterococci cases, about 43% (9132/21,339) of cases were from the infants aged (<1-year old) and 32% (6745/21,339) from the adult patients. No changes observed in vancomycin, teicoplanin, and linezolid susceptibility; however, E. faecium and E. faecalis blood culture isolates remained highly susceptible (>97%) to these antibiotics. (4): Conclusions: The current study revealed a significant increase of E. faecalis and E. faecium blood culture isolates as compared to the previous national ESKAPE data. Low vancomycin resistance was observed. Continuous monitoring of antimicrobial resistant Enterococcus species is warranted in South Africa.
摘要：
(1)背景：肠球菌多药耐药的出现是一个主要的公共卫生问题。这项研究旨在确定南非公立医院在五年期间（2016-2020年）从血液培养物中分离的肠球菌的患病率和耐药性。（2）：方法：对南非公立医院从血流感染样本中分离出的临床肠球菌进行了回顾性分析。2016年1月至2020年12月的ESKAPE数据集是从国家卫生实验室服务（NHLS）的中央数据仓库（CDW）获得的。(3):结果:重复数据消除后，从血液培养物中分离出的130,352/306,592种生物被鉴定为ESKAPE病原体。在这项研究中,肺炎克雷伯菌（25%；33,082/130,352），是血液培养中最常见的病原体，其次是金黄色葡萄球菌（23％；29,922/130,352）和肠球菌（16％；21,339/130,352）。肠球菌病例中，约43%(9132/21,339)的病例来自年龄(<1岁)的婴儿，32%(6745/21,339)的病例来自成年患者。万古霉素没有变化，替考拉宁,和利奈唑胺敏感性；然而，屎肠球菌和粪肠球菌血液培养分离株仍然对这些抗生素高度敏感(97%)。(4):结论:与先前的国家ESKAPE数据相比,本研究揭示粪肠球菌和屎肠球菌血培养分离物的显著增加。观察到低万古霉素抗性。在南非，有必要对耐药肠球菌进行持续监测。
