PDF(Pubmed)
Abstract：
CD161 has been linked to the appearance and development of various cancers.
The mutation map and the variation of CNVs and SNVs of CD161 were displayed according to cBioportal and GSCALite. We also evaluated the pathway enrichment and drug sensitivity of CD161 according to GSCALite. We performed a single-cell sequencing analysis of cancer cells and T cells in melanoma. The cell communication patterns related to CD161 were further explored. Multiplex immunofluorescence staining of tissue microarrays was used to detect the association between CD161 expression and macrophages and T cells.
A high CD161 level was related to neoantigens expression, pathway enrichment, and drug sensitivity. In addition, single-cell sequencing analysis showed that CD161 was mainly expressed in T cells, M1 and M2 Macrophages, neoplastic, microglial cells, neurons, and cancer cells in many tumor types. Further study on pseudotime trajectories and functional annotation of CD161 proved the critical role of CD161 in tumor progression and T cell immunity in melanoma. Multiplex immunofluorescence revealed that CD161 is closely correlated with the immune infiltration of T cells and macrophages in multiple cancers. In addition, high CD161 expression predicted a favorable immunotherapy response.
CD161 is involved in the immune infiltration of T cells and macrophages and might be a promising target for tumor immunotherapy.
The mutation map and the variation of CNVs and SNVs of CD161 were displayed according to cBioportal and GSCALite. We also evaluated the pathway enrichment and drug sensitivity of CD161 according to GSCALite. We performed a single-cell sequencing analysis of cancer cells and T cells in melanoma. The cell communication patterns related to CD161 were further explored. Multiplex immunofluorescence staining of tissue microarrays was used to detect the association between CD161 expression and macrophages and T cells.
A high CD161 level was related to neoantigens expression, pathway enrichment, and drug sensitivity. In addition, single-cell sequencing analysis showed that CD161 was mainly expressed in T cells, M1 and M2 Macrophages, neoplastic, microglial cells, neurons, and cancer cells in many tumor types. Further study on pseudotime trajectories and functional annotation of CD161 proved the critical role of CD161 in tumor progression and T cell immunity in melanoma. Multiplex immunofluorescence revealed that CD161 is closely correlated with the immune infiltration of T cells and macrophages in multiple cancers. In addition, high CD161 expression predicted a favorable immunotherapy response.
CD161 is involved in the immune infiltration of T cells and macrophages and might be a promising target for tumor immunotherapy.
摘要：
未经证实：CD161与各种癌症的出现和发展有关。
未授权：根据cBioportal和GSCALite显示CD161的突变图谱和CNVs和SNVs的变异。我们还根据GSCALite评估了CD161的途径富集和药物敏感性。我们对黑色素瘤中的癌细胞和T细胞进行了单细胞测序分析。进一步探讨了与CD161相关的细胞通讯模式。组织微阵列的多重免疫荧光染色用于检测CD161表达与巨噬细胞和T细胞之间的关联。
未经证实：高CD161水平与新抗原表达有关，途径富集，和药物敏感性。此外,单细胞测序分析显示CD161主要表达于T细胞,M1和M2巨噬细胞，肿瘤，小胶质细胞，神经元，和许多肿瘤类型的癌细胞。对CD161的假时间轨迹和功能注释的进一步研究证明了CD161在黑色素瘤的肿瘤进展和T细胞免疫中的关键作用。多重免疫荧光显示，CD161与多种癌症中T细胞和巨噬细胞的免疫浸润密切相关。此外,高CD161表达预测良好的免疫治疗反应。
未经证实：CD161参与T细胞和巨噬细胞的免疫浸润，可能是肿瘤免疫治疗的一个有希望的靶点。
未授权：根据cBioportal和GSCALite显示CD161的突变图谱和CNVs和SNVs的变异。我们还根据GSCALite评估了CD161的途径富集和药物敏感性。我们对黑色素瘤中的癌细胞和T细胞进行了单细胞测序分析。进一步探讨了与CD161相关的细胞通讯模式。组织微阵列的多重免疫荧光染色用于检测CD161表达与巨噬细胞和T细胞之间的关联。
未经证实：高CD161水平与新抗原表达有关，途径富集，和药物敏感性。此外,单细胞测序分析显示CD161主要表达于T细胞,M1和M2巨噬细胞，肿瘤，小胶质细胞，神经元，和许多肿瘤类型的癌细胞。对CD161的假时间轨迹和功能注释的进一步研究证明了CD161在黑色素瘤的肿瘤进展和T细胞免疫中的关键作用。多重免疫荧光显示，CD161与多种癌症中T细胞和巨噬细胞的免疫浸润密切相关。此外,高CD161表达预测良好的免疫治疗反应。
未经证实：CD161参与T细胞和巨噬细胞的免疫浸润，可能是肿瘤免疫治疗的一个有希望的靶点。
