PDF(Pubmed)
Abstract：
UNASSIGNED: In emergency and non-fasting patients posted for laparotomy under general anaesthesia, rapid sequence induction (RSI) is preferred, and it is routinely done by using succinylcholine or rocuronium. Using higher doses of atracurium [i.e. 3-4 times the 95% effective dose (ED95)] can provide acceptable intubating conditions in a short time. The primary objective of our study was to compare two different higher doses of atracurium to achieve good intubating conditions for RSI without using a priming dose. The secondary objective was to compare the duration of muscle relaxation using neuromuscular monitoring and haemodynamic responses during and after intubation.
UNASSIGNED: Sixty patients were enroled and randomly assigned into two groups:-, group A1 (atracurium: 0.75 mg/kg) and group A2 (atracurium: 1 mg/kg). After premedication, anaesthesia was induced with propofol 2-2.5 mg/kg and atracurium injections, followed by intubation within a minute by trained anaesthesiologists. Meanwhile, intubating conditions, neuromuscular monitoring using train-of-four (TOF) measurements and post-tetanic-count and haemodynamics were recorded. Data were analysed statistically by using the Chi-square test and Student\'s t-test.
UNASSIGNED: Excellent intubation conditions (without coughing or bucking) were attained in 56.7% of cases in group A2 and in 13.3% in group A1 (P < 0.001). Duration of muscle relaxation, measured by time until TOF is two, was more prolonged in group A2 (79.2 ± 9.2 min) than in group A1 (60.13 ± 8.7 min, P < 0.001).
UNASSIGNED: Acceptable intubating conditions can be achieved in a minute with the use of a high dose of atracurium (1 mg/kg) during RSI. Hence, atracurium can be used as an alternative drug for RSI.
UNASSIGNED: Sixty patients were enroled and randomly assigned into two groups:-, group A1 (atracurium: 0.75 mg/kg) and group A2 (atracurium: 1 mg/kg). After premedication, anaesthesia was induced with propofol 2-2.5 mg/kg and atracurium injections, followed by intubation within a minute by trained anaesthesiologists. Meanwhile, intubating conditions, neuromuscular monitoring using train-of-four (TOF) measurements and post-tetanic-count and haemodynamics were recorded. Data were analysed statistically by using the Chi-square test and Student\'s t-test.
UNASSIGNED: Excellent intubation conditions (without coughing or bucking) were attained in 56.7% of cases in group A2 and in 13.3% in group A1 (P < 0.001). Duration of muscle relaxation, measured by time until TOF is two, was more prolonged in group A2 (79.2 ± 9.2 min) than in group A1 (60.13 ± 8.7 min, P < 0.001).
UNASSIGNED: Acceptable intubating conditions can be achieved in a minute with the use of a high dose of atracurium (1 mg/kg) during RSI. Hence, atracurium can be used as an alternative drug for RSI.
摘要：
未经授权：在全身麻醉下进行剖腹手术的急诊和非禁食患者中，快速序列诱导（RSI）是优选的，通常使用琥珀酰胆碱或罗库溴铵。使用较高剂量的阿曲库铵[即95%有效剂量(ED95)的3-4倍]可以在短时间内提供可接受的插管条件。我们研究的主要目的是比较两种不同的较高剂量的阿曲库铵，以在不使用引发剂量的情况下实现RSI的良好插管条件。次要目的是使用神经肌肉监测和插管期间和之后的血流动力学反应来比较肌肉松弛的持续时间。
未经评估：60名患者被纳入并随机分为两组：A1组(阿曲库铵:0.75mg/kg)和A2组(阿曲库铵:1mg/kg)。用药后,用丙泊酚2-2.5mg/kg和阿曲库铵注射诱导麻醉，然后在一分钟内由训练有素的麻醉师插管。同时,插管条件,使用四组训练(TOF)测量和强直后计数和血流动力学进行神经肌肉监测。数据采用卡方检验和学生t检验进行统计分析。
UNASSIGNED：在A2组中56.7％的病例和A1组中13.3％的病例达到了良好的插管条件（无咳嗽或咳嗽）（P<0.001）。肌肉放松的持续时间，按时间测量，直到TOF为2，A2组(79.2±9.2min)比A1组(60.13±8.7min,P<0.001)。
UNASSIGNED：在RSI期间使用高剂量的阿曲库铵（1mg/kg）可以在一分钟内实现可接受的插管条件。因此，阿曲库铵可用作RSI的替代药物。
未经评估：60名患者被纳入并随机分为两组：A1组(阿曲库铵:0.75mg/kg)和A2组(阿曲库铵:1mg/kg)。用药后,用丙泊酚2-2.5mg/kg和阿曲库铵注射诱导麻醉，然后在一分钟内由训练有素的麻醉师插管。同时,插管条件,使用四组训练(TOF)测量和强直后计数和血流动力学进行神经肌肉监测。数据采用卡方检验和学生t检验进行统计分析。
UNASSIGNED：在A2组中56.7％的病例和A1组中13.3％的病例达到了良好的插管条件（无咳嗽或咳嗽）（P<0.001）。肌肉放松的持续时间，按时间测量，直到TOF为2，A2组(79.2±9.2min)比A1组(60.13±8.7min,P<0.001)。
UNASSIGNED：在RSI期间使用高剂量的阿曲库铵（1mg/kg）可以在一分钟内实现可接受的插管条件。因此，阿曲库铵可用作RSI的替代药物。
