PDF(Pubmed)
Abstract：
UNASSIGNED: Anadara granosa (blood clam) shell contained 98.7% of calcium carbonate (CaCO3). This material has bio-properties that able to induced the dentin regeneration. This study is expected to reveal the nuclear factor kappa beta (NF-kB), transforming growth factor beta (TGF-β1), and vascular endothelial growth factor A (VEGF-A) expression in dental pulp after application of CaCO3 from Anadara granosa shell.
UNASSIGNED: The thirty Rattus norvegicus strain Wistar used as model. The maxillary first molar was preparation using 0.84 mm low-speed diamond bur to made cavity. The cavity then applied glass ionomer cement (as control group) and other group applied CaCO3 from Anadara granosa shell. The teeth in each group were extracted after 1st, 3rd and 7th days of application for immunohistochemistry analysis for NF-kB, TGF-β1, and VEGF-A expression.
UNASSIGNED: The NF-kB expression in the group with CaCO3 from Anadara granosa shell lower than control after 1st, 3rd and 7th days (p < 0.05). In other hand, the TGF-β1 and VEGF-A expression in the group with CaCO3 from Anadara granosa shell higher than control after 1st, 3rd and 7th days (p < 0.05).
UNASSIGNED: CaCO3 from Anadara granosa shell able to stimulate the TGF-β1 and VEGF-A and suppress the NF-kB expression in the dental pulp. This material able to develop as dentin-pulp material restoration.
UNASSIGNED: The thirty Rattus norvegicus strain Wistar used as model. The maxillary first molar was preparation using 0.84 mm low-speed diamond bur to made cavity. The cavity then applied glass ionomer cement (as control group) and other group applied CaCO3 from Anadara granosa shell. The teeth in each group were extracted after 1st, 3rd and 7th days of application for immunohistochemistry analysis for NF-kB, TGF-β1, and VEGF-A expression.
UNASSIGNED: The NF-kB expression in the group with CaCO3 from Anadara granosa shell lower than control after 1st, 3rd and 7th days (p < 0.05). In other hand, the TGF-β1 and VEGF-A expression in the group with CaCO3 from Anadara granosa shell higher than control after 1st, 3rd and 7th days (p < 0.05).
UNASSIGNED: CaCO3 from Anadara granosa shell able to stimulate the TGF-β1 and VEGF-A and suppress the NF-kB expression in the dental pulp. This material able to develop as dentin-pulp material restoration.
摘要：
未经证实：Anadaragranosa（血蛤壳）壳含有98.7%的碳酸钙（CaCO3）。该材料具有能够诱导牙本质再生的生物特性。本研究有望揭示核因子κβ（NF-kB），转化生长因子β（TGF-β1），应用来自Anadaragranosa壳的CaCO3后，牙髓中血管内皮生长因子A（VEGF-A）的表达。
UnASSIGNED：将30个褐家鼠品系Wistar用作模型。上颌第一磨牙是使用0.84mm低速金刚石钻头制备的。然后，空腔应用玻璃离聚物水泥（作为对照组），其他组应用来自Anadaragranosa壳的CaCO3。每组的牙齿在1号后拔除，用于NF-kB的免疫组织化学分析的第3天和第7天，TGF-β1和VEGF-A表达。
UNASSIGNED：1后，来自Anadaragranosa壳的CaCO3组的NF-kB表达低于对照组，第3天和第7天(p<0.05)。另一方面,1岁后，阿纳达拉颗粒壳CaCO3组的TGF-β1和VEGF-A表达高于对照组，第3天和第7天(p<0.05)。
未经证实：来自Anadaragranosa壳的CaCO3能够刺激TGF-β1和VEGF-A并抑制牙髓中NF-kB的表达。这种材料能够发展为牙本质-牙髓材料修复。
UnASSIGNED：将30个褐家鼠品系Wistar用作模型。上颌第一磨牙是使用0.84mm低速金刚石钻头制备的。然后，空腔应用玻璃离聚物水泥（作为对照组），其他组应用来自Anadaragranosa壳的CaCO3。每组的牙齿在1号后拔除，用于NF-kB的免疫组织化学分析的第3天和第7天，TGF-β1和VEGF-A表达。
UNASSIGNED：1后，来自Anadaragranosa壳的CaCO3组的NF-kB表达低于对照组，第3天和第7天(p<0.05)。另一方面,1岁后，阿纳达拉颗粒壳CaCO3组的TGF-β1和VEGF-A表达高于对照组，第3天和第7天(p<0.05)。
未经证实：来自Anadaragranosa壳的CaCO3能够刺激TGF-β1和VEGF-A并抑制牙髓中NF-kB的表达。这种材料能够发展为牙本质-牙髓材料修复。
