Abstract：
This study explores familial psychiatric risk factors that are closely linked to suicide risk among patients with opioid use disorder (OUD) as measured by the Family History Assessment Module (FHAM). Data was derived from adults diagnosed with OUD (N = 389). To analyze the covariance between the 11 items of the FHAM, principal component analysis was applied to infer principal components (PC) scores. Log-binominal regression was conducted to quantify the associations between PC scores and mental health symptoms (e.g., lifetime suicidal attempt, P30D suicidal ideation, depression, and anxiety). Analyses revealed that the first 3 three PCs could account for 56% of the total variance of the FHAM items within the data. Family history of substance misuse (PC1) was positively associated with lifetime suicide attempts and severe anxiety. Family history of serious mental illness (PC2) and of suicidal behavior (PC3) were not significantly associated with any outcomes. Our findings suggest current suicide risk is associated with an array of familial psychiatric issues among people with OUD. However, family history of suicide attempts and death by suicide has less bearing on current suicide risk in OUD patients whereas family history of substance use confers significant risk. Findings underscore suicide-related preventive interventions as necessary components of treatment plans among people with OUD, who commonly report family histories of substance misuse.
摘要：
这项研究探讨了通过家族史评估模块（FHAM）测量的与阿片类药物使用障碍（OUD）患者自杀风险密切相关的家族性精神病风险因素。数据来自诊断为OUD的成年人（N=389）。为了分析FHAM的11个项目之间的协方差，应用主成分分析推断主成分(PC)得分。进行对数二项回归以量化PC评分与心理健康症状之间的关联(例如，一生的自杀企图,P30D自杀意念,抑郁症,和焦虑）。分析显示，前3三个PC可以占数据中FHAM项目总方差的56％。药物滥用家族史（PC1）与终生自杀企图和严重焦虑呈正相关。严重精神疾病（PC2）和自杀行为（PC3）的家族史与任何结局均无明显相关性。我们的发现表明，目前的自杀风险与OUD患者的一系列家族性精神病有关。然而,自杀未遂和自杀死亡的家族史对OUD患者当前自杀风险的影响较小,而药物使用的家族史赋予了显著的风险.研究结果强调了与自杀相关的预防性干预措施是OUD患者治疗计划的必要组成部分，通常报告药物滥用家族史的人。
