Abstract：
The present review aims to provide an overview of methods for the quantification of 2,5-dimethoxy-amphetamines and -phenethylamines in different biological matrices, both traditional and alternative ones.
A complete literature search was carried out with PubMed, Scopus and the World Wide Web using relevant keywords, e.g., designer drugs, amphetamines, phenethylamines, and biological matrices.
Synthetic phenethylamines represent one of the largest classes of \"designer drugs\", obtained through chemical structure modifications of psychoactive substances to increase their pharmacological activities. This practice is also favored by the fact that every new synthetic compound is not considered illegal by existing legislation. Generally, in a toxicological laboratory, the first monitoring of drugs of abuse is made by rapid screening tests that sometimes can occur in false positive or false negative results. To reduce evaluation errors, it is mandatory to submit the positive samples to confirmatory methods, such as gas chromatography or liquid chromatography combined to mass spectrometry, for a more specific qualitative and quantitative analysis.
This review highlights the great need for updated comprehensive analytical methods, particularly when analyzing biological matrices, both traditional and alternative ones, for the search of newly emerging designer drugs.
A complete literature search was carried out with PubMed, Scopus and the World Wide Web using relevant keywords, e.g., designer drugs, amphetamines, phenethylamines, and biological matrices.
Synthetic phenethylamines represent one of the largest classes of \"designer drugs\", obtained through chemical structure modifications of psychoactive substances to increase their pharmacological activities. This practice is also favored by the fact that every new synthetic compound is not considered illegal by existing legislation. Generally, in a toxicological laboratory, the first monitoring of drugs of abuse is made by rapid screening tests that sometimes can occur in false positive or false negative results. To reduce evaluation errors, it is mandatory to submit the positive samples to confirmatory methods, such as gas chromatography or liquid chromatography combined to mass spectrometry, for a more specific qualitative and quantitative analysis.
This review highlights the great need for updated comprehensive analytical methods, particularly when analyzing biological matrices, both traditional and alternative ones, for the search of newly emerging designer drugs.
摘要：
目的：本综述旨在概述不同生物基质中2,5-二甲氧基苯丙胺和苯丙胺的定量方法，传统的和另类的。
方法：使用PubMed进行了完整的文献检索，Scopus和万维网使用相关关键字，例如，设计药物，安非他明,苯乙胺，和生物基质。
结果：合成苯乙胺代表了“设计药物”的最大类别之一，通过对精神活性物质进行化学结构修饰以增加其药理活性而获得。这种做法也受到现有立法不认为每种新合成化合物都是非法的事实的青睐。一般来说,在毒理学实验室，滥用药物的首次监测是通过快速筛查测试进行的，有时会出现假阳性或假阴性结果。为了减少评估错误，必须将阳性样本提交确认方法，如气相色谱或液相色谱与质谱联用，进行更具体的定性和定量分析。
结论：这篇综述强调了对更新的综合分析方法的巨大需求，特别是在分析生物基质时，传统的和另类的，寻找新出现的设计药物。
方法：使用PubMed进行了完整的文献检索，Scopus和万维网使用相关关键字，例如，设计药物，安非他明,苯乙胺，和生物基质。
结果：合成苯乙胺代表了“设计药物”的最大类别之一，通过对精神活性物质进行化学结构修饰以增加其药理活性而获得。这种做法也受到现有立法不认为每种新合成化合物都是非法的事实的青睐。一般来说,在毒理学实验室，滥用药物的首次监测是通过快速筛查测试进行的，有时会出现假阳性或假阴性结果。为了减少评估错误，必须将阳性样本提交确认方法，如气相色谱或液相色谱与质谱联用，进行更具体的定性和定量分析。
结论：这篇综述强调了对更新的综合分析方法的巨大需求，特别是在分析生物基质时，传统的和另类的，寻找新出现的设计药物。
