Abstract：
Pregnant women are one of the endangered groups who need special attention in the COVID-19 epidemic. We conducted a systematic review and summarised the studies that reported adverse pregnancy outcomes in pregnant women with COVID-19 infection. A literature search was performed in PubMed and Scopus up to 1 September 2022, for retrieving original articles published in the English language assessing the association between COVID-19 infection and adverse pregnancy outcomes. Finally, in this review study, of 1790 articles obtained in the initial search, 141 eligible studies including 1,843,278 pregnant women were reviewed. We also performed a meta-analysis of a total of 74 cohort and case-control studies. In this meta-analysis, both fixed and random effect models were used. Publication bias was also assessed by Egger\'s test and the trim and fill method was conducted in case of a significant result, to adjust the bias. The result of the meta-analysis showed that the pooled prevalence of preterm delivery, maternal mortality, NICU admission and neonatal death in the group with COVID-19 infection was significantly more than those without COVID-19 infection (p<.01). A meta-regression was conducted using the income level of countries. COVID-19 infection during pregnancy may cause adverse pregnancy outcomes including of preterm delivery, maternal mortality, NICU admission and neonatal death. Pregnancy loss and SARS-CoV2 positive neonates in Lower middle income are higher than in High income. Vertical transmission from mother to foetus may occur, but its immediate and long-term effects on the newborn are unclear.
摘要：
孕妇是COVID-19疫情中需要特别关注的濒危群体之一。我们进行了系统评价，并总结了报告COVID-19感染孕妇不良妊娠结局的研究。截至2022年9月1日，在PubMed和Scopus进行了文献检索，以检索以英语发表的评估COVID-19感染与不良妊娠结局之间关联的原始文章。最后,在这项综述研究中，在最初搜索中获得的1790篇文章中，审查了141项符合条件的研究，包括1,843,278名孕妇。我们还对总共74项队列和病例对照研究进行了荟萃分析。在这个荟萃分析中，采用固定效应模型和随机效应模型.出版偏倚也通过Egger测试进行评估，并在结果显着的情况下进行修剪和填充方法。来调整偏差。荟萃分析的结果表明，早产的汇总患病率，孕产妇死亡率,COVID-19感染组的NICU入院和新生儿死亡人数明显高于无COVID-19感染组（p<0.01）。使用各国收入水平进行元回归。怀孕期间感染COVID-19可能导致不良妊娠结局，包括早产，孕产妇死亡率,NICU入院和新生儿死亡。中低收入家庭的妊娠损失和SARS-CoV2阳性新生儿高于高收入家庭。从母亲到胎儿的垂直传播可能发生，但其对新生儿的直接和长期影响尚不清楚。
