Patients with chronic (CP, n = 16) or aggressive periodontitis (AP, n = 15) and periodontally healthy controls (n = 32) were recruited. Body mass index was calculated. Glycemia, plasma insulin, glycated hemoglobin, C-reactive protein, and lipid levels were measured in fasting. The Homeostasis Model Assessment was used to calculate the insulin sensitivity (HOMA-%S), the beta-cell function (HOMA-%B), and their hyperbolic product (HOMA-%BxS).
The CP group showed statistically significantly insulin resistance with a lower HOMA-%S (p = 0.0003) and a reduced HOMA-%BxS (p = 0.049) despite a higher insulin level (p = 0.01) vs the control group, even after BMI adjustment. There was also a trend to dysglycemia (prediabetes/diabetes) in the chronic group. In patients with AP, no abnormalities in insulin status were observed and glycemic levels were comparable with controls. Additionally, patients in both AP and CP groups presented significantly higher CRP levels compared to those of the control group (p = 0.02).
Patients with CP showed reduced insulin sensitivity, increased insulin levels but a reduced %BxS product and a trend to dysglycemia. These abnormalities were not observed in AP.
方法:慢性(CP,n=16)或侵袭性牙周炎(AP,n=15)和牙周健康对照(n=32)被招募。计算体重指数。血糖,血浆胰岛素,糖化血红蛋白,C反应蛋白,空腹时测量血脂水平。稳态模型评估用于计算胰岛素敏感性(HOMA-%S),β细胞功能(HOMA-%B),和它们的双曲线乘积(HOMA-%BxS)。
结果:尽管胰岛素水平较高(p=0.01),CP组显示出统计学上显著的胰岛素抵抗,HOMA-%S较低(p=0.0003)和HOMA-%BxS较低(p=0.049)。即使在BMI调整后。在慢性组中也存在血糖异常(前驱糖尿病/糖尿病)的趋势。在AP患者中,未观察到胰岛素状态异常,血糖水平与对照组相当.此外,AP组和CP组患者的CRP水平明显高于对照组(p=0.02).
结论:CP患者显示胰岛素敏感性降低,胰岛素水平增加,但BxS产物%降低,并有血糖异常的趋势。在AP中未观察到这些异常。