UNASSIGNED: After reviewing the medical records, we divided cardiovascular surgery patients treated at our central campus into two groups: the baseline group (treated between January 2012 and December 2013) and the intervention group (treated between May 2014 and December 2020). Intervention measures consisted of preoperative nasal screening and targeted decolonization bundle therapy. The medical records of patients at our southern campus (treated between January 2017 and December 2020) were collected as an additional control group, since we did not implement SA intervention measures at this location. The incidences of SA/MRSA-related NI were then compared between the groups.
UNASSIGNED: There were 794 patients in the baseline group and 2,826 in the intervention group. A total of 131 (4.6%) patients had SA nasal colonization, and among them, 33 patients (1.2%) were MRSA colonized. SA/MRSA was cleared in approximately 95% of the carriers. The total level of SA-related infection was significantly lower in the intervention group compared to the baseline group [0.354% vs. 1.133%, respectively; P=0.021; risk ratio (RR): 0.312; 95% confidence interval (CI): 0.127-0.766]. The incidence of MRSA-related infection followed the same trend (0.212% vs. 0.756%, respectively; P=0.030; RR: 0.281; 95% CI: 0.091-0.860). When compared to the southern campus, SA intervention measures at the central campus resulted in a significant reduction in total SA-related infection (1.132% vs. 0.284%, respectively; P=0.035; RR: 0.251; 95% CI: 0.077-0.820).
UNASSIGNED: The prevalence of SA/MRSA colonization is relatively low among Chinese patients who received cardiovascular surgery. Targeted decolonization bundle therapy was associated with cleared colonization and reduced incidence of SA/MRSA-related infection.
未经评估:查看病历后,我们将中心校区接受治疗的心血管手术患者分为两组:基线组(2012年1月至2013年12月接受治疗)和干预组(2014年5月至2020年12月接受治疗).干预措施包括术前鼻腔筛查和靶向去定植集束化治疗。收集我们南校区患者的病历(2017年1月至2020年12月期间治疗)作为额外的对照组,因为我们没有在这个地方实施SA干预措施。然后比较各组间SA/MRSA相关NI的发生率。
UNASSIGNED:基线组794例,干预组2,826例。共有131例(4.6%)患者有SA鼻腔定植,其中,33例(1.2%)MRSA定植。在大约95%的载体中,SA/MRSA被清除。与基线组相比,干预组SA相关感染的总水平显着降低[0.354%vs.1.133%,分别为;P=0.021;风险比(RR):0.312;95%置信区间(CI):0.127-0.766]。MRSA相关感染的发生率遵循相同的趋势(0.212%vs.0.756%,分别为;P=0.030;RR:0.281;95%CI:0.091-0.860)。与南校区相比,中心校园的SA干预措施显着减少了SA相关的总感染(1.132%vs.0.284%,分别为;P=0.035;RR:0.251;95%CI:0.077-0.820)。
UNASSIGNED:在接受心血管手术的中国患者中,SA/MRSA定植的患病率相对较低。靶向去定植集束化治疗与清除定植和降低SA/MRSA相关感染的发生率相关。