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Abstract：
UNASSIGNED: Nonalcoholic fatty liver disease (NAFLD) is the commonest type of liver disease worldwide. We aimed to assess the incidence and predictors of liver-related events (LREs) and mortality in NAFLD patients.
UNASSIGNED: NAFLD patients (n = 957) evaluated between January 2000 and November 2021 were included. Patients were categorised as noncirrhosis (NC), compensated cirrhosis (CC) and decompensated cirrhosis (DC), and the incidence of LRE and mortality were estimated and compared.
UNASSIGNED: The proportions of NC, CC and DC were 87.8% (n = 840), 8.8% (n = 84) and 3.4% (n = 33), respectively. The median follow-up duration was 3.9 (3.0-5.7) years, and the total cumulative duration was 4633 person-years. The incidence of LRE per 100 person-years was 0.14, 2.72 and 10.24 in patients with NC, CC and DC, respectively. The incidence of mortality was 0.12, 1.05 and 4.24 per 100 person-years, respectively, in the 3 groups. The causes of mortality in the 3 groups were liver related in 1/5 (20%), 3/4 (75%) and 6/9 (66.7%), respectively. Overall, the mortality rate was higher in those with diabetes than those without diabetes (log-rank P value = 0.005). On further analysis, diabetes was associated with poor outcomes only in NC group (log-rank P value = 0.036), and not in CC (log-rank P value = 0.353) or DC groups (log-rank P value = 0.771). On multivariate Cox proportional hazard analysis, age (hazard ratio [HR] 1.070), hypertension (HR 4.361) and DC (HR 15.036) were independent predictors of poor outcomes. Liver stiffness measurement, bilirubin, CC and DC were independent predictors of LRE.
UNASSIGNED: In our study of NAFLD from India, the incidence of LRE was found to be similar to that seen in Western studies. In NC NAFLD, diabetes was associated with poor outcomes.
UNASSIGNED: NAFLD patients (n = 957) evaluated between January 2000 and November 2021 were included. Patients were categorised as noncirrhosis (NC), compensated cirrhosis (CC) and decompensated cirrhosis (DC), and the incidence of LRE and mortality were estimated and compared.
UNASSIGNED: The proportions of NC, CC and DC were 87.8% (n = 840), 8.8% (n = 84) and 3.4% (n = 33), respectively. The median follow-up duration was 3.9 (3.0-5.7) years, and the total cumulative duration was 4633 person-years. The incidence of LRE per 100 person-years was 0.14, 2.72 and 10.24 in patients with NC, CC and DC, respectively. The incidence of mortality was 0.12, 1.05 and 4.24 per 100 person-years, respectively, in the 3 groups. The causes of mortality in the 3 groups were liver related in 1/5 (20%), 3/4 (75%) and 6/9 (66.7%), respectively. Overall, the mortality rate was higher in those with diabetes than those without diabetes (log-rank P value = 0.005). On further analysis, diabetes was associated with poor outcomes only in NC group (log-rank P value = 0.036), and not in CC (log-rank P value = 0.353) or DC groups (log-rank P value = 0.771). On multivariate Cox proportional hazard analysis, age (hazard ratio [HR] 1.070), hypertension (HR 4.361) and DC (HR 15.036) were independent predictors of poor outcomes. Liver stiffness measurement, bilirubin, CC and DC were independent predictors of LRE.
UNASSIGNED: In our study of NAFLD from India, the incidence of LRE was found to be similar to that seen in Western studies. In NC NAFLD, diabetes was associated with poor outcomes.
摘要：
未经证实：非酒精性脂肪性肝病（NAFLD）是全球最常见的肝病类型。我们旨在评估NAFLD患者肝脏相关事件（LRE）和死亡率的发生率和预测因素。
未经评估：纳入2000年1月至2021年11月评估的NAFLD患者（n=957）。患者被归类为非肝硬化（NC），代偿性肝硬化（CC）和失代偿性肝硬化（DC），估计并比较了LRE的发生率和死亡率。
未经评估：NC的比例，CC和DC为87.8%(n=840)，8.8%(n=84)和3.4%(n=33)，分别。中位随访时间为3.9（3.0-5.7）年，总累积持续时间为4633人年。在NC患者中，每100人年的LRE发生率分别为0.14、2.72和10.24，CC和DC，分别。死亡率为0.12,1.05和4.24/100人年,分别,在3组。3组死亡原因均为肝脏相关的1/5(20%),3/4（75%）和6/9（66.7%），分别。总的来说,糖尿病患者的死亡率高于无糖尿病患者(log-rankP值=0.005).进一步分析,糖尿病仅在NC组中与不良预后相关（log-rankP值=0.036），并且不在CC组（对数秩P值=0.353）或DC组（对数秩P值=0.771）中。关于多元Cox比例风险分析，年龄(危险比[HR]1.070)，高血压(HR4.361)和DC(HR15.036)是不良结局的独立预测因子.肝脏硬度测量，胆红素,CC和DC是LRE的独立预测因子。
未经批准：在我们对印度NAFLD的研究中，发现LRE的发病率与西方研究相似.在NCNAFLD中，糖尿病与不良结局相关.
未经评估：纳入2000年1月至2021年11月评估的NAFLD患者（n=957）。患者被归类为非肝硬化（NC），代偿性肝硬化（CC）和失代偿性肝硬化（DC），估计并比较了LRE的发生率和死亡率。
未经评估：NC的比例，CC和DC为87.8%(n=840)，8.8%(n=84)和3.4%(n=33)，分别。中位随访时间为3.9（3.0-5.7）年，总累积持续时间为4633人年。在NC患者中，每100人年的LRE发生率分别为0.14、2.72和10.24，CC和DC，分别。死亡率为0.12,1.05和4.24/100人年,分别,在3组。3组死亡原因均为肝脏相关的1/5(20%),3/4（75%）和6/9（66.7%），分别。总的来说,糖尿病患者的死亡率高于无糖尿病患者(log-rankP值=0.005).进一步分析,糖尿病仅在NC组中与不良预后相关（log-rankP值=0.036），并且不在CC组（对数秩P值=0.353）或DC组（对数秩P值=0.771）中。关于多元Cox比例风险分析，年龄(危险比[HR]1.070)，高血压(HR4.361)和DC(HR15.036)是不良结局的独立预测因子.肝脏硬度测量，胆红素,CC和DC是LRE的独立预测因子。
未经批准：在我们对印度NAFLD的研究中，发现LRE的发病率与西方研究相似.在NCNAFLD中，糖尿病与不良结局相关.
