PDF(Pubmed)
Abstract：
UNASSIGNED: Adherence to medication(s) is an essential component of holistic management in any chronic disease including in post liver transplant (LT) patients. Thus, this study aimed to assess adherence to medications in Indian pediatric liver disease patients (including post LT recipients) and to identify variables affecting its occurrence.
UNASSIGNED: A cross-sectional study was conducted among pediatric (<18 years of age) subjects with Wilson disease (WD) and autoimmune liver disease (AILD) along with post LT recipients from May 2021 to October 2021. Structured tools using prevalidated questionnaires (Medication adherence measure and the Child & Adolescent Adherence to Medication Questionnaire) were used to collect data related to nonadherence prevalence (based on missed and late doses) and factors influencing the adherence.
UNASSIGNED: A total of 152 children were included in the study (WD 39.5%, AILD 32.9%, and post LT 27.6%). Prevalence of missed and late dose nonadherence (at a cut-off of ≥20%) was 12.5% and 16.4%, respectively. Older age (odd\'s ratio/O.R 1.185), stay in a rural area (O.R 5.08), and barriers like bad taste of medication (O.R 4.728) and hard to remember the medication (O.R 7.180) were independently associated with nonadherence (P < 0.05).
UNASSIGNED: Overall, nonadherence was seen in 12-16%, i.e., around one-sixth of the patients, with least nonadherence seen in post LT recipients (0-2.4%). Older age of the patient, rural place of stay and personal barriers like hard to remember/forgetfulness and bad medication taste were identified as factors independently leading to nonadherence.
UNASSIGNED: A cross-sectional study was conducted among pediatric (<18 years of age) subjects with Wilson disease (WD) and autoimmune liver disease (AILD) along with post LT recipients from May 2021 to October 2021. Structured tools using prevalidated questionnaires (Medication adherence measure and the Child & Adolescent Adherence to Medication Questionnaire) were used to collect data related to nonadherence prevalence (based on missed and late doses) and factors influencing the adherence.
UNASSIGNED: A total of 152 children were included in the study (WD 39.5%, AILD 32.9%, and post LT 27.6%). Prevalence of missed and late dose nonadherence (at a cut-off of ≥20%) was 12.5% and 16.4%, respectively. Older age (odd\'s ratio/O.R 1.185), stay in a rural area (O.R 5.08), and barriers like bad taste of medication (O.R 4.728) and hard to remember the medication (O.R 7.180) were independently associated with nonadherence (P < 0.05).
UNASSIGNED: Overall, nonadherence was seen in 12-16%, i.e., around one-sixth of the patients, with least nonadherence seen in post LT recipients (0-2.4%). Older age of the patient, rural place of stay and personal barriers like hard to remember/forgetfulness and bad medication taste were identified as factors independently leading to nonadherence.
摘要：
未经评估：坚持药物治疗是包括肝移植（LT）后患者在内的任何慢性疾病的整体管理的重要组成部分。因此，本研究旨在评估印度儿童肝病患者(包括LT术后患者)对药物治疗的依从性,并确定影响其发生的变量.
UNASSIGNED：从2021年5月至2021年10月，对患有Wilson病（WD）和自身免疫性肝病（AILD）的儿科（<18岁）受试者以及LT后接受者进行了一项横断面研究。使用预先验证问卷（药物依从性测量和儿童和青少年对药物依从性问卷）的结构化工具来收集与不依从性患病率（基于错过和晚期剂量）和影响依从性的因素相关的数据。
未经评估：共有152名儿童被纳入研究（WD39.5％，AILD32.9%，和后期27.6%）。错过和晚期剂量不依从性的患病率（在≥20％的临界值）为12.5％和16.4％，分别。年龄较大（奇数/O。R1.185),留在农村地区（O.R5.08),和障碍，如不良口味的药物（O.R4.728）和难以记住的药物（O。R7.180）与不依从性独立相关（P<0.05）。
未经评估：总的来说，12-16%的患者不依从，即，大约六分之一的病人，在LT后接受者中观察到的不依从最少（0-2.4%）。患者年龄较大，农村居住地和难以记住/健忘和不良药物口味等个人障碍被确定为导致不依从性的独立因素。
UNASSIGNED：从2021年5月至2021年10月，对患有Wilson病（WD）和自身免疫性肝病（AILD）的儿科（<18岁）受试者以及LT后接受者进行了一项横断面研究。使用预先验证问卷（药物依从性测量和儿童和青少年对药物依从性问卷）的结构化工具来收集与不依从性患病率（基于错过和晚期剂量）和影响依从性的因素相关的数据。
未经评估：共有152名儿童被纳入研究（WD39.5％，AILD32.9%，和后期27.6%）。错过和晚期剂量不依从性的患病率（在≥20％的临界值）为12.5％和16.4％，分别。年龄较大（奇数/O。R1.185),留在农村地区（O.R5.08),和障碍，如不良口味的药物（O.R4.728）和难以记住的药物（O。R7.180）与不依从性独立相关（P<0.05）。
未经评估：总的来说，12-16%的患者不依从，即，大约六分之一的病人，在LT后接受者中观察到的不依从最少（0-2.4%）。患者年龄较大，农村居住地和难以记住/健忘和不良药物口味等个人障碍被确定为导致不依从性的独立因素。
