Abstract：
The Striatin family of proteins constitutes Striatin, SG2NA, and Zinedin. Members of this family of proteins act as a signaling scaffold due to the presence of multiple protein-protein interaction domains. At least two members of this family, namely Zinedin and SG2NA, have a proven role in cancer cell proliferation. SG2NA, the second member of this family, undergoes alternative splicing and gives rise to several isoforms which are differentially regulated in a tissue-dependent manner. SG2NA evolved earlier than the other two members of the family, and SG2NA undergoes not only alternative splicing but also other posttranscriptional gene regulation. Striatin also undergoes alternative splicing, and as a result, it gives rise to multiple isoforms. It has been shown that this family of proteins plays a significant role in estrogen signaling, neuroprotection, cancer as well as in cell cycle regulation. Members of the striatin family form a complex network of signaling hubs with different kinases and phosphatases, and other signaling proteins named STRIPAK. Here, in the present manuscript, we thoroughly reviewed the findings on striatin family members to elaborate on the overall structural and functional idea of this family of proteins. We also commented on the involvement of these proteins in STRIPAK complexes and their functional relevance.
摘要：
纹状体蛋白家族的蛋白质构成纹状体蛋白，SG2NA,还有Zinedin.由于存在多个蛋白质-蛋白质相互作用结构域，该蛋白质家族的成员充当信号传导支架。这个家庭至少有两个成员,即Zinedin和SG2NA，在癌细胞增殖中有被证实的作用。SG2NA,这个家庭的第二个成员，经历选择性剪接并产生几种以组织依赖性方式差异调节的同工型。SG2NA比家族的其他两个成员更早进化，SG2NA不仅经历选择性剪接，而且还经历其他转录后基因调控。纹状体也经历选择性剪接，结果，它产生多个同工型。研究表明，该蛋白质家族在雌激素信号传导中起着重要作用，神经保护,癌症以及细胞周期调控。纹状体蛋白家族的成员形成具有不同激酶和磷酸酶的信号中枢的复杂网络,和其他名为STRIPAK的信号蛋白。这里,在目前的手稿中，我们对纹状体蛋白家族成员的研究结果进行了全面回顾，以阐述该蛋白家族的整体结构和功能概念。我们还评论了这些蛋白质在STRIPAK复合物中的参与及其功能相关性。
