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Abstract：
UNASSIGNED: To evaluate the accuracy of Mycobacterium tuberculosis (MTB)-RNA in the rapid diagnosis of lymph node tuberculosis (LNTB). Moreover, the difference in the diagnostic accuracy of MTB-RNA using different specimens was determined.
UNASSIGNED: We included patients with suspected LNTB who met the inclusion criteria and retrospectively analyzed their clinical data. The sensitivity, specificity, positive-predictive value (PPV), negative-predictive value (NPV), and area under the curve (AUC) of MTB-RNA and culture were calculated and its diagnostic accuracy for LNTB was evaluated in comparison with the final clinical diagnosis.
UNASSIGNED: Overall, 285 patients were included in the study. The overall sensitivity, specificity, PPV, NPV, and AUC of MTB-RNA were 40.6%, 100.0%, 100.0%, 17.0%, and 0.70, respectively. These values were 30.8%, 100.0%, 100.0%, 16.0%, and 0.65, respectively, for tissue specimens; 34.2%, 100.0%, 100.0%, 24.6%, and 0.67, respectively, for puncture specimens; and 57.14%, 100.0%, 100.0%, 5.3%, and 0.79, respectively, for pus specimens. These values of culture were 24.4%, 100.0%, 100.0%, 13.9%, and 0.62, respectively, for all specimens; 17.6%, 100.0%, 100.0%, 13.8%, and 0.59, respectively, for tissue specimens; 25.3%, 100.0%, 100.0%, 22.4%, and 0.63, respectively, for puncture specimens; and 31.0%, 100.0%, 100.0%, 3.3%, and 0.65, respectively, for pus specimens.
UNASSIGNED: The diagnostic efficacy of MTB-RNA for the rapid diagnosis of LNTB was moderate, but its sensitivity was low. The lymph node pus specimens were the most sensitive for MTB-RNA testing, followed by puncture specimens; tissues were the least sensitive. Pus specimens should be preferably obtained in case only this test is to be used for diagnosis.
UNASSIGNED: We included patients with suspected LNTB who met the inclusion criteria and retrospectively analyzed their clinical data. The sensitivity, specificity, positive-predictive value (PPV), negative-predictive value (NPV), and area under the curve (AUC) of MTB-RNA and culture were calculated and its diagnostic accuracy for LNTB was evaluated in comparison with the final clinical diagnosis.
UNASSIGNED: Overall, 285 patients were included in the study. The overall sensitivity, specificity, PPV, NPV, and AUC of MTB-RNA were 40.6%, 100.0%, 100.0%, 17.0%, and 0.70, respectively. These values were 30.8%, 100.0%, 100.0%, 16.0%, and 0.65, respectively, for tissue specimens; 34.2%, 100.0%, 100.0%, 24.6%, and 0.67, respectively, for puncture specimens; and 57.14%, 100.0%, 100.0%, 5.3%, and 0.79, respectively, for pus specimens. These values of culture were 24.4%, 100.0%, 100.0%, 13.9%, and 0.62, respectively, for all specimens; 17.6%, 100.0%, 100.0%, 13.8%, and 0.59, respectively, for tissue specimens; 25.3%, 100.0%, 100.0%, 22.4%, and 0.63, respectively, for puncture specimens; and 31.0%, 100.0%, 100.0%, 3.3%, and 0.65, respectively, for pus specimens.
UNASSIGNED: The diagnostic efficacy of MTB-RNA for the rapid diagnosis of LNTB was moderate, but its sensitivity was low. The lymph node pus specimens were the most sensitive for MTB-RNA testing, followed by puncture specimens; tissues were the least sensitive. Pus specimens should be preferably obtained in case only this test is to be used for diagnosis.
摘要：
UNASSIGNED：评估结核分枝杆菌（MTB）-RNA在淋巴结结核（LNTB）快速诊断中的准确性。此外，确定使用不同标本的MTB-RNA诊断准确性的差异。
UNASSIGNED：我们纳入了符合纳入标准的疑似LNTB患者，并对其临床资料进行回顾性分析。敏感性,特异性，阳性预测值(PPV)，负预测值(NPV)，计算MTB-RNA和培养物的曲线下面积（AUC），并与最终临床诊断进行比较，评估其对LNTB的诊断准确性。
未经评估：总的来说，285名患者被纳入研究。整体灵敏度,特异性，PPV,NPV,MTB-RNA的AUC为40.6%,100.0%,100.0%,17.0%,和0.70。这些值是30.8%,100.0%,100.0%,16.0%,和0.65，分别组织标本；34.2%，100.0%,100.0%,24.6%,和分别为0.67，穿刺标本；57.14%，100.0%,100.0%,5.3%,和0.79，分别用于脓液标本。这些培养值为24.4%，100.0%,100.0%,13.9%,和分别为0.62，所有标本；17.6%，100.0%,100.0%,13.8%,和分别为0.59，组织标本；25.3%，100.0%,100.0%,22.4%,和分别为0.63，穿刺标本；31.0%，100.0%,100.0%,3.3%,和0.65，分别用于脓液标本。
UNASSIGNED：MTB-RNA对LNTB的快速诊断的诊断功效中等，但它的灵敏度很低。淋巴结脓液标本对MTB-RNA检测最敏感,其次是穿刺标本；组织最不敏感。如果仅将此测试用于诊断，则应优选获得脓液标本。
UNASSIGNED：我们纳入了符合纳入标准的疑似LNTB患者，并对其临床资料进行回顾性分析。敏感性,特异性，阳性预测值(PPV)，负预测值(NPV)，计算MTB-RNA和培养物的曲线下面积（AUC），并与最终临床诊断进行比较，评估其对LNTB的诊断准确性。
未经评估：总的来说，285名患者被纳入研究。整体灵敏度,特异性，PPV,NPV,MTB-RNA的AUC为40.6%,100.0%,100.0%,17.0%,和0.70。这些值是30.8%,100.0%,100.0%,16.0%,和0.65，分别组织标本；34.2%，100.0%,100.0%,24.6%,和分别为0.67，穿刺标本；57.14%，100.0%,100.0%,5.3%,和0.79，分别用于脓液标本。这些培养值为24.4%，100.0%,100.0%,13.9%,和分别为0.62，所有标本；17.6%，100.0%,100.0%,13.8%,和分别为0.59，组织标本；25.3%，100.0%,100.0%,22.4%,和分别为0.63，穿刺标本；31.0%，100.0%,100.0%,3.3%,和0.65，分别用于脓液标本。
UNASSIGNED：MTB-RNA对LNTB的快速诊断的诊断功效中等，但它的灵敏度很低。淋巴结脓液标本对MTB-RNA检测最敏感,其次是穿刺标本；组织最不敏感。如果仅将此测试用于诊断，则应优选获得脓液标本。
