UNASSIGNED: This was a pure experimental research on Wistar rats with a post-test control group design. Five experimental groups (X1, X2, X3, X4, X5) were given 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg, and 0.6 mg of low-density polyethylene microplastics mixed in 2cc distilled water, respectively. Furthermore, except for control (C), the groups received microplastics an oral probe for 90 days.
UNASSIGNED: The molecular response of hippocampal neurons of Wistar rats to microplastics in the blood significantly decreased SOD enzyme expression, while CAT enzyme was unaffected. It considerably increased neuronal membrane damage (expression of MDA), increased considerably neuronal deoxyribonucleic acid damage (expression of 8-OHdG), and decreased blood serum Aβ42 levels (pathway analysis, all t-value >1.96).
UNASSIGNED: The pathway analysis showed that hippocampal neurons were significantly affected by microplastic particles in the blood.
UNASSIGNED:这是对Wistar大鼠的纯实验研究,具有测试后对照组设计。5个实验组(X1,X2,X3,X4,X5)分别给予0.0375mg,0.075毫克,0.15毫克,0.3mg,和0.6毫克低密度聚乙烯微塑料混合在2cc蒸馏水中,分别。此外,除对照(C)外,这些小组接受了90天的微塑料口腔探针。
UNASSIGNED:Wistar大鼠海马神经元对血液中微塑料的分子反应明显降低了SOD酶的表达,而CAT酶不受影响。它大大增加了神经元膜损伤(MDA的表达),显著增加神经元脱氧核糖核酸损伤(8-OHdG的表达),和降低血清Aβ42水平(途径分析,所有t值>1.96)。
UNASSIGNED:通路分析表明,海马神经元受到血液中的微塑料颗粒的显着影响。