PDF(Pubmed)
Abstract：
UNASSIGNED: Low-density polyethylene microplastics are ingested into the bloodstream and distributed to all the organ tissue, including the hippocampus, causing toxic effects. This research aimed to elucidate the responses of hippocampal neurons to microplastic in the blood based on the expressions of superoxide dismutase (SOD), catalase (CAT) enzymes, malondialdehyde (MDA), 8-oxo-7,8-dihydro-2-deoxyguanosine (8-OHdG) in hippocampal neurons, and blood serum amyloid beta 1-42 (Aβ42) levels using SMART PLS pathway analysis.
UNASSIGNED: This was a pure experimental research on Wistar rats with a post-test control group design. Five experimental groups (X1, X2, X3, X4, X5) were given 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg, and 0.6 mg of low-density polyethylene microplastics mixed in 2cc distilled water, respectively. Furthermore, except for control (C), the groups received microplastics an oral probe for 90 days.
UNASSIGNED: The molecular response of hippocampal neurons of Wistar rats to microplastics in the blood significantly decreased SOD enzyme expression, while CAT enzyme was unaffected. It considerably increased neuronal membrane damage (expression of MDA), increased considerably neuronal deoxyribonucleic acid damage (expression of 8-OHdG), and decreased blood serum Aβ42 levels (pathway analysis, all t-value >1.96).
UNASSIGNED: The pathway analysis showed that hippocampal neurons were significantly affected by microplastic particles in the blood.
UNASSIGNED: This was a pure experimental research on Wistar rats with a post-test control group design. Five experimental groups (X1, X2, X3, X4, X5) were given 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg, and 0.6 mg of low-density polyethylene microplastics mixed in 2cc distilled water, respectively. Furthermore, except for control (C), the groups received microplastics an oral probe for 90 days.
UNASSIGNED: The molecular response of hippocampal neurons of Wistar rats to microplastics in the blood significantly decreased SOD enzyme expression, while CAT enzyme was unaffected. It considerably increased neuronal membrane damage (expression of MDA), increased considerably neuronal deoxyribonucleic acid damage (expression of 8-OHdG), and decreased blood serum Aβ42 levels (pathway analysis, all t-value >1.96).
UNASSIGNED: The pathway analysis showed that hippocampal neurons were significantly affected by microplastic particles in the blood.
摘要：
UNASSIGNED：低密度聚乙烯微塑料被摄入血液并分布到所有器官组织，包括海马,造成毒性作用。本研究以超氧化物歧化酶(SOD)的表达为基础,阐明海马神经元对血液微塑料的反应,过氧化氢酶（CAT）酶，丙二醛（MDA），海马神经元中的8-氧代-7,8-二氢-2-脱氧鸟苷（8-OHdG），使用SMARTPLS途径分析和血清淀粉样β1-42（Aβ42）水平。
UNASSIGNED：这是对Wistar大鼠的纯实验研究，具有测试后对照组设计。5个实验组(X1,X2,X3,X4,X5)分别给予0.0375mg,0.075毫克，0.15毫克，0.3mg,和0.6毫克低密度聚乙烯微塑料混合在2cc蒸馏水中，分别。此外，除对照(C)外，这些小组接受了90天的微塑料口腔探针。
UNASSIGNED：Wistar大鼠海马神经元对血液中微塑料的分子反应明显降低了SOD酶的表达，而CAT酶不受影响。它大大增加了神经元膜损伤（MDA的表达），显著增加神经元脱氧核糖核酸损伤（8-OHdG的表达），和降低血清Aβ42水平(途径分析，所有t值>1.96)。
UNASSIGNED：通路分析表明，海马神经元受到血液中的微塑料颗粒的显着影响。
UNASSIGNED：这是对Wistar大鼠的纯实验研究，具有测试后对照组设计。5个实验组(X1,X2,X3,X4,X5)分别给予0.0375mg,0.075毫克，0.15毫克，0.3mg,和0.6毫克低密度聚乙烯微塑料混合在2cc蒸馏水中，分别。此外，除对照(C)外，这些小组接受了90天的微塑料口腔探针。
UNASSIGNED：Wistar大鼠海马神经元对血液中微塑料的分子反应明显降低了SOD酶的表达，而CAT酶不受影响。它大大增加了神经元膜损伤（MDA的表达），显著增加神经元脱氧核糖核酸损伤（8-OHdG的表达），和降低血清Aβ42水平(途径分析，所有t值>1.96)。
UNASSIGNED：通路分析表明，海马神经元受到血液中的微塑料颗粒的显着影响。
