PDF(Pubmed)
Abstract：
Bone-related diseases refer to a group of skeletal disorders that are characterized by bone and cartilage destruction. Conventional approaches can regulate bone homeostasis to a certain extent. However, these therapies are still associated with some undesirable problems. Fortunately, recent advances in nanomaterials have provided unprecedented opportunities for diagnosis and therapy of bone-related diseases. This review provides a comprehensive and up-to-date overview of current advanced theranostic nanomaterials in bone-related diseases. First, the potential utility of nanomaterials for biological imaging and biomarker detection is illustrated. Second, nanomaterials serve as therapeutic delivery platforms with special functions for bone homeostasis regulation and cellular modulation are highlighted. Finally, perspectives in this field are offered, including current key bottlenecks and future directions, which may be helpful for exploiting nanomaterials with novel properties and unique functions. This review will provide scientific guidance to enhance the development of advanced nanomaterials for the diagnosis and therapy of bone-related diseases.
摘要：
骨相关疾病是指一组以骨和软骨破坏为特征的骨骼疾病。常规方法可以在一定程度上调节骨稳态。然而,这些疗法仍然伴随着一些不良问题。幸运的是,纳米材料的最新进展为骨相关疾病的诊断和治疗提供了前所未有的机会。这篇综述提供了目前在骨相关疾病中的先进治疗纳米材料的全面和最新概述。首先,说明了纳米材料用于生物成像和生物标志物检测的潜在用途。第二,纳米材料作为治疗输送平台，具有骨稳态调节和细胞调节的特殊功能。最后,提供了这一领域的观点，包括当前的主要瓶颈和未来的发展方向，这可能有助于开发具有新颖性能和独特功能的纳米材料。这篇综述将为促进先进纳米材料在骨相关疾病的诊断和治疗中的发展提供科学指导。
